1987
DOI: 10.1016/0040-8166(87)90072-3
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Identification of smooth muscle-derived foam cells in the atherosclerotic plaque of human aorta with monoclonal antibody IIG10

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Cited by 18 publications
(11 citation statements)
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“…2 However, it has been established for many years that atherosclerotic lesions also contain abundant foam cells with a vascular smooth muscle cell (VSMC) identity. [3][4][5] Consistent with this, VSMCs in culture can accrue neutral lipids when challenged with hyperlipidemic serum or atherogenic lipoproteins. 6,7 See accompanying article on page 535…”
supporting
confidence: 52%
“…2 However, it has been established for many years that atherosclerotic lesions also contain abundant foam cells with a vascular smooth muscle cell (VSMC) identity. [3][4][5] Consistent with this, VSMCs in culture can accrue neutral lipids when challenged with hyperlipidemic serum or atherogenic lipoproteins. 6,7 See accompanying article on page 535…”
supporting
confidence: 52%
“…Mouse mAb 4.29.AB raised against human pFN and cross reacting with different mammalian FN was kindly provided by Dr. M. Chemousov (Institute of Experimental Cardiology, Cardiology Research Center, Moscow, USSR). For staining of rat aorta sections ascites fluid was diluted 1:100. mAb IIG10, raised against cultured human aortic SMCs, recognizes a surface antigen of SMCs and fibroblasts; endothelial cells, macrophages/ monocytes, peripheral blood lymphocytes, etc., were shown to be IIG10 negative (19). The IgM fraction purified from ascites fluid was diluted to 50 #g/ml for immunostaining.…”
Section: Methodsmentioning
confidence: 99%
“…aggregates [32] Monocyte migration [32] Monocyte adhesion [22] β 1 integrin [41] P-selectin [42] TFPI [43] Thrombomodulin [44] Metalloproteinase [46] Angiogenesis [46,47] Foam cell formation [49] Foam cell formation [57] Membrane fluidity [71] CD11b/CD18 [71] NETosis [73] Chemotaxis [51] Proliferation [52] Phenotypic switch [53] Active TF [54,55] Foam cell formation [32] THROMBO-INFLAMMATORY EFFECTS…”
Section: Endothelial Cells Smooth Muscle Cells Monocytes/macrophages mentioning
confidence: 99%
“…Inflammatory stimuli lead to VSMC activation and the secretion of matrix metalloproteinases. Furthermore, similarly to macrophages, SMCs can transform into foam cells [49].…”
Section: Oxidized Lipoproteins and Vascular Smcs (Vsmcs)mentioning
confidence: 99%