Identification of Small Peptides of Acidic Collagen Extracts from Silver Carp Skin and Their Therapeutic Relevance

Wojtkowiak, Diana; Frydrychowski, Andrzej F.; Hadzik, Jakub; Dominiak, Marzena

doi:10.17219/acem/36361

Cited by 5 publications

(5 citation statements)

References 53 publications

(68 reference statements)

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“…Based on earlier findings, collagen extracted with the acidic method from the skin of silver carp ( H. molitrix ) indicates the skin reconstructive treatment potential of acidic collagen extracts acquired from the skin of silver carp containing considerable amounts of small 7–29 peptides. Therefore, the application of these peptides could result in beneficial clinical effects in patients needing reconstructive treatment [ 199 ]. A fish market in Fuzhou, China, supplied another useful silver carp fish skin to form freshwater-derived collagen in the form of collagen/chitosan/chondroitin sulfate scaffolds.…”

Section: Tissue Engineering and Regenerative Medicinesmentioning

confidence: 99%

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Panggabean¹,

Adiguna²,

Hardhiyuna

et al. 2023

Marine Drugs

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Aquatic-based collagens have attracted much interest due to their great potential application for biomedical sectors, including the tissue engineering sector, as a major component of the extracellular matrix in humans. Their physical and biochemical characteristics offer advantages over mammalian-based collagen; for example, they have excellent biocompatibility and biodegradability, are easy to extract, and pose a relatively low immunological risk to mammalian products. The utilization of aquatic-based collagen also has fewer religious restrictions and lower production costs. Aquatic-based collagen also creates high-added value and good environmental sustainability by aquatic waste utilization. Thus, this study aims to overview aquatic collagen’s characteristics, extraction, and fabrication. It also highlights its potential application for tissue engineering and the regeneration of bone, cartilage, dental, skin, and vascular tissue. Moreover, this review highlights the recent research in aquatic collagen, future prospects, and challenges for it as an alternative biomaterial for tissue engineering and regenerative medicines.

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Section: Tissue Engineering and Regenerative Medicinesmentioning

confidence: 99%

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Panggabean¹,

Adiguna²,

Hardhiyuna

et al. 2023

Marine Drugs

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“…During the extraction, the collagen may be broken by solvent. The acidic collagen extracts acquired from the skin of the silver carp contain considerable quantities of small peptides (Wojtkowiak et al, 2016).…”

Section: Chemical Hydrolysismentioning

confidence: 99%

Potential Health Functions of Collagen Bioactive Peptides: A Review

Chen¹,

Li²,

Huang³

2020

American Journal of Biochemistry and Biotechnology

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Collagen is the most abundant protein in nature and widely exits in animals. However collagen usage is not good enough, which is a waste of natural resources and an environmental burden. Collagen peptides have some special characters and functions. These functions can decide their usage. Therefore producing, discovering and using new functional collagen peptides are promising way to deal with this issue. Collagen peptides are produced by hydrolysing collagen or gelatin via chemical or biochemical methods. Biochemical hydrolysation is more proper to produce functional collagen peptides than chemical hydrolysation. The collagen hydrolysates or peptides have four levels of functions: Nutrition, basic functions, special biological functions and other useful properties. The nutrition is providing amino acids and small peptides. The basic functions are improving the state of connective tissues, such as skin and bone. The special biology functions include antioxidant, antihypertensive and other bioactive benefits. Other useful functions include antifreeze, metal chelation and forming edible film. All these functions decide that they can be used in food as well as other fields. The present work is a compilation of current information on the preparations and functions of collagen peptides. At last, recommendation for the further research of collagen peptides is proposed.

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“…This is favorable in the sense that silver carp skin-derived peptide separation using extraction with organic solvents, e.g. chloroform, leads to active peptides with some degree of hydrophobicity [10], which in turn allows the peptides to be concentrated in a simple manner for use in cosmetic and medicinal products. Another important characteristic of small peptides is their effective penetration into the dermis, which has been confirmed for fish peptides obtained by extraction with enzymes [30].…”

Section: The Effect Of Collagen Peptides On the Hsp701 Human Gene Prmentioning

confidence: 99%

“…In a previous study the authors used mass spectrometry to demonstrate that fish skin contains small peptides (containing 7-29 amino acid residues) which could be potential matrikines [10]. The most common peptides were derived from decorin, lumican and α1, α2 and α3 chains of type I collagen, among others.…”

mentioning

confidence: 99%

The Effect of Silver Carp Skin-Derived Peptides on the Activities of VEGF and Hsp70.1 Gene Transcription Promoters

et al. 2016

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ing to replace animal collagen with another type, e.g. fish collagen [1].Studies on extracellular matrix proteins, including collagen, elastin, laminin and proteoglycans (among others), have revealed that they participate in the regulation of key cellular processes such as cell migration, adhesion and differentiation, organogenesis, mitogenesis and apoptosis [2]. This regulation is mediated by signal peptides, so-called matrikines, produced after a partial proteolysis of the matrix components; this term was first proposed by Maquart to define peptides that For over 20 years collagen of animal origin has been one of the hopes for elaborating novel therapeutic strategies. Studies conducted on animal models have demonstrated that collagen-derived peptides can be beneficial in fighting cancer, accelerating wound healing, and repairing damaged neurons, among other applications. However, all these studies were conducted using animal collagen samples, most often originating from bovine or porcine skin. Currently, due to reported cases of bovine spongiform encephalopathy (BSE) and foot-and-mouth disease ( AbstractBackground. Studies conducted on human cell culture models have demonstrated that collagen-derived peptides can exert a beneficial effect in medicine. However, all these studies were conducted using animal collagen samples, most often originating from bovine or porcine skin. Currently attempts are being made to replace animal collagen with fish collagen. Objectives. The aim of the study was to compare the effect of silver carp skin-derived peptide extract on the transcriptional activities of human VEGF and hsp70.1 gene promoters inserted into the plasmids with secreted alkaline phosphatase as a reporter gene. Material and Methods. Changes in the activity of the promoters were investigated using a HEK293FT cell line transfected with pVEGF-SEAP or pHsp70-SEAP. The cells were cultured in dishes containing peptides separated using reverse-phase high performance liquid chromatography. Results. The study demonstrated that the silver carp skin-derived peptide extract exerts both an inhibitory effect on the VEGF gene promoter and activating effect on the hsp70.1 gene promoter. Higher biological activity was recorded in the case of a freshly prepared peptide extract compared to one stored at 4°C for three months. Conclusions. The silver carp skin-derived collagen peptides influence VEGF and hsp70.1 gene promoters' transcriptional activity (Adv Clin Exp Med 2016, 25, 3, 415-423).

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Identification of Small Peptides of Acidic Collagen Extracts from Silver Carp Skin and Their Therapeutic Relevance

Cited by 5 publications

References 53 publications

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Cutting Edge Aquatic-Based Collagens in Tissue Engineering

Potential Health Functions of Collagen Bioactive Peptides: A Review

The Effect of Silver Carp Skin-Derived Peptides on the Activities of VEGF and Hsp70.1 Gene Transcription Promoters

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