Identification of side of seizure onset in temporal lobe epilepsy using memory tests in the context of reading deficits

Ji, Breier; Bl, Brookshire; Jm, Fletcher; Ab, Thomas; Pm, Plenger; Jw, Wheless; Lj, Willmore; Papanicolaou, Andrew C.

doi:10.1080/01688639708403847

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…The control group differed significantly from the TLE group in IQ ( p , .01). The difference in IQ is consistent with the level of intellectual ability reported in previous studies of TLE (e.g., Breier et al, 1997;Camfield et al, 1984;Glosser et al, 1997;Hermann & Wyler, 1988). It is also consistent with the association between early age of onset of recurrent seizures and poorer cognitive functioning.…”

Section: Introductionsupporting

confidence: 87%

Narrative and procedural discourse in temporal lobe epilepsy

Bell

Dow

Watson

et al. 2003

J Int Neuropsychol Soc

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It is well established that some individuals with temporal lobe epilepsy (TLE) demonstrate language deficits at the single word level. However, discourse production rarely has been examined quantitatively within this group. This study compared adult TLE patients with an early seizure onset (< or = age 14 years, n = 27) to a control group (n = 28) on narrative and procedural discourse tasks. As a group, the TLE patients performed normally on the procedural discourse task, but differed significantly from the controls on several narrative discourse variables. At the individual level, 30% of the TLE patients versus 4% of the controls demonstrated impaired discourse ability (p and 0.01). Within this early onset TLE group, discourse performance was not associated with demographic or seizure history variables. Considering the cognitive domain, discourse performance correlated significantly with working memory. In summary, mild discourse dysfunction was present in a significant minority of early onset TLE patients, but this deficit was not closely associated with other language measures. Discourse ability and its neuropsychological, neuroanatomical and conversational speech correlates deserve further study in TLE patients.

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Section: Introductionsupporting

confidence: 87%

Narrative and procedural discourse in temporal lobe epilepsy

Bell

Dow

Watson

et al. 2003

J Int Neuropsychol Soc

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“…This is supported by studies suggesting that tests using material that is more difficult to verbalize (e.g, dot locations or random patterns) typically revealed stronger associations between visual memory performance and RTLE or right hippocampus resections [16–19] than tests using abstract designs [20–22]. Functional neuroimaging studies also support this by indicating that the type of stimuli (e.g., line drawings) often used in visual memory tests are affected by verbal interference paradigms and reflect fMRI activation in verbal areas of the brain[23].…”

Section: Introductionmentioning

confidence: 69%

“…Furthermore, there appears to be a lack of sensitivity of line designs to RTLE even when drawing is not required such as on the Visual Spatial Learning Test [22]. A detailed discussion of visual memory in TLE is beyond the focus of this article, however, alternative stimuli with some empirical support includes dot locations on an asymmetrical circle array [19], dot locations on a selective reminding test [16], and faces [20, 51]. Regardless, these and other studies suggest that alternatives to drawing-based should be further explored among epilepsy patients.…”

Section: Discussionmentioning

confidence: 99%

Influence of anxiety on memory performance in temporal lobe epilepsy

Brown

Westerveld

Langfitt

et al. 2014

Epilepsy & Behavior

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This study examined the degree to which anxiety contributed to inconsistent material-specific memory difficulties among 243 temporal lobe epilepsy patients from the Multisite Epilepsy Study. Visual memory performance on the Rey Complex Figure Test (RCFT) was lower for those with high versus low level of anxiety, but was not found to be related to side of TLE. Verbal memory on the California Verbal Learning Test (CVLT) was significantly lower for left than right TLE patients with low anxiety, but equally impaired for those with high anxiety. These results suggest that we can place more confidence in the ability of verbal memory tests like the CVLT to lateralize to left TLE for those with low anxiety, but that verbal memory will be less likely to produce lateralizing information for those with high anxiety. This suggests that more caution is needed when interpreting verbal memory tests for those with high anxiety. These results indicated that RCFT performance was significantly affected by anxiety and did not lateralize to either side, regardless of anxiety level. This study adds to the existing literature which suggests that drawing-based visual memory tests do not lateralize among TLE patients, regardless of anxiety level.

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“…For example, and Hermann, Seidenberg, Haltiner, and Wyler (1992) found a signi®cant relationship between degree of language impairment and recall performance on a verbal memory 190 MELISSA OGDEN-EPKER AND C. MUNRO CULLUM task. Along these lines, Breier et al (1997) demonstrated that reading abilities in¯uenced verbal / nonverbal lateralization ®ndings, as subjects with impaired reading skills (regardless of side of seizure origin) were correctly classi®ed as left or right TLE at a lower rate and incorrectly classi®ed more often than those subjects without a reading de®cit. Thus, it appears language skills may provide independent lateralizing information, as well as impact performance on verbal memory measures.…”

Section: Discussionmentioning

confidence: 95%

Quantitative and Qualitative Interpretation of Neuropsychological Data in the Assessment of Temporal Lobectomy Candidates

Ogden-Epker¹,

Cullum²

2001

The Clinical Neuropsychologist

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Neuropsychologists who serve as members of an epilepsy surgery team are often asked to provide information regarding localized cerebral dysfunction that may relate to the seizure focus in patients with intractable temporal lobe epilepsy (TLE). However, the rate at which neuropsychological (NP) assessment results correspond with the side of seizure focus (i.e., left vs. right) in TLE patients is unknown. The majority of literature in this area has focused on the ability of single NP tests to detect lateralized cognitive dysfunction in groups of TLE patients, with mixed findings and few consistent replications. The primary purpose of this study was to examine the rate at which qualitative clinician interpretations of NP profiles agree with seizure lateralization as determined by a multidisciplinary surgery team in temporal lobectomy candidates. Quantitative analyses of single NP test scores and groups of test scores (i.e., cognitive domain composite scores) were also conducted to examine their effectiveness in discriminating left from right TLE groups. Only four of the 19 NP test variables and three of the nine composite cognitive domain scores significantly differed between the groups. However, clinician interpretation of NP profiles agreed with the surgery conference team's determination of seizure laterality in two-thirds of cases. These findings suggest that qualitative aspects of NP performance play an important role in identifying lateralized cerebral dysfunction in TLE patients, and provide additional support for the use of NP assessment results in the selection of temporal lobectomy candidates.

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Identification of side of seizure onset in temporal lobe epilepsy using memory tests in the context of reading deficits

Cited by 17 publications

References 33 publications

Narrative and procedural discourse in temporal lobe epilepsy

Narrative and procedural discourse in temporal lobe epilepsy

Influence of anxiety on memory performance in temporal lobe epilepsy

Quantitative and Qualitative Interpretation of Neuropsychological Data in the Assessment of Temporal Lobectomy Candidates

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