Identification of sialyl oligosaccharides including an oligosaccharide nucleotide in colostrum of an addax (<i>Addax nasomaculatus</i>) (Subfamily Antelopinae)

Ganzorig, Khuukhenbaatar; Takuya, Asakawa; Sasaki, Motomasa; Saito, Tadao; Suzuki, Isao; Fukuda, Kenji; Urashima, Tadasu

doi:10.1111/asj.12899

Cited by 8 publications

(5 citation statements)

References 22 publications

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“…Based on these chemical shifts, the third saccharide in this fraction was characterized as Neu5Gc(α2-6)Gal(β1-4)GlcNAc (6’-Neu5GcLN, EGCII 1-4-3). The anomeric shifts of this fraction were similar to those from the AC 2-5-3 fraction of addax colostrum reported by Ganzorig et al (2018) .…”

Section: Resultssupporting

confidence: 87%

“…Oligosaccharide reference materials (see Table 1 for abbreviations) 3’-SL and 6’-SL were obtained from Sigma-Aldrich (St. Louis, MO, USA). 3’-Neu5GCL was isolated from Greater Galago milk ( Taufik et al, 2012 ), 6’-NeuGcL was isolated from caprine and ovine colostrum ( Nakamura et al, 1998 ; Urashima et al, 1997 ), 6’-SLN was isolated from caprine colostrum ( Urashima et al., 1997 ) and 6’-Neu5GCLN was isolated from addax colostrum ( Ganzorig et al, 2018 ).…”

Section: Methodsmentioning

confidence: 99%

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Characterization of Bioactive Sialyl Oligosaccharides Separated from Colostrum of Indonesia Dairy Goat

Taufik¹,

Arief²,

Budiman³

et al. 2022

Food Sci Anim Resour

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The bioactive functions of oligosaccharides from human milk have been reported by many studies. Many of oligosaccharides isolated from colostrum and/or milk of dairy animals have been reported to have similar chemical structures with those in human colostrum and/or milk. It has been proved by several studies that the oligosaccharides with similar chemical structure shared common bioactivities. Among domesticated dairy animals, bovine/cattle, caprine/goat, and ovine/sheep are the most commonly used species to isolate oligosaccharides from their colostrum and/or milk. Several studies on the oligosaccharides from goat colostrum and milk have revealed similar properties to that of human milk and possess the highest content of sialyl oligosaccharides (SOS) as compared to other ruminants. Indonesia ranks first in Association of Southeast Asian Nations (ASEAN) for goat milk production. Therefore, goat milk is the second most consumed milk in the country. The most reared dairy goat breed in Indonesia is Etawah Grade. However, oligosaccharides from Indonesia dairy animals including goat, have not been characterized. This is the first study to characterize oligosaccharides from Indonesia dairy animals. The present study was aimed to isolate and characterize oligosaccharides, specifically SOS from the colostrum of Etawah Grade goats by using proton/ 1 H-nuclear magnetic resonance. The SOS successfully characterized in this study were: Neu5Ac(α2-3)Gal(β1-4)Glc (3’-N-acetylneuraminyllactose), Neu5Ac(α2-6)Gal(β1-4)Glc (6’-N-acetylneuraminyllactose), Neu5Gc(α2-3)Gal(β1-4)Glc (3’-N-glycolylneuraminyllactose), Neu5Gc(α2-6)Gal(β1-4)Glc (6’-N-glycolylneuraminyllactose), Neu5Ac(α2-6)Gal(β1-4) GlcNAc (6’-N-acetylneuraminyllactosamine) and Neu5Gc(α2-6)Gal(β1-4)GlcNAc (6’-N-glycolylneuraminyllactosamine). This finding shows that Etawah Grade, as a local dairy goat breed in Indonesia, is having significant potential to be natural source of oligosaccharides that can be utilized in the future food and pharmaceutical industries.

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Section: Resultssupporting

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Characterization of Bioactive Sialyl Oligosaccharides Separated from Colostrum of Indonesia Dairy Goat

Taufik¹,

Arief²,

Budiman³

et al. 2022

Food Sci Anim Resour

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show abstract

“…Several structures, such as Neu5Acα2-3Galα1-3Galβ1-4Glc (Supplementary Dataset 1, slide 47), have, to our knowledge, never been described as a MO and represents a new glycan sequence, sialyl-a3GL. Other bovines, such as Addax nasomaculatus 30 , Bos taurus 16,31 , or Bubalus bubalis 12 , share characteristics such as extended sialic acids, usage of Neu5Gc, and lactosamine-based MOs, supporting their conservation in this family.…”

Section: Lacdinac Is Widespread In Mos Of Artiodactyla Speciesmentioning

confidence: 94%

Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc

Jin

Lundstrøm

Korhonen

et al. 2023

Preprint

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Breast milk is abundant with functionalized milk oligosaccharides (MOs), to nourish and protect the neonate. Yet we lack a comprehensive understanding of the repertoire and evolution of MOs across Mammalia. We report ≈400 MO-species associations (>100 novel structures) from milk glycomics of nine mostly understudied species: alpaca, beluga whale, black rhinoceros, bottlenose dolphin, impala, L'Hoest's monkey, pygmy hippopotamus, domestic sheep, and striped dolphin. This revealed the hitherto unknown existence of the LacdiNAc motif (GalNAcβ1-4GlcNAc) in MOs of all species except alpaca, sheep, and striped dolphin, indicating widespread occurrence of this potentially antimicrobial motif in MOs. We also characterize glucuronic acid-containing MOs in the milk of impala, dolphins, sheep, and rhinoceros, previously only reported in cows. We demonstrate that these GlcA-MOs exhibit potent immunomodulatory effects. Our study extends the number of known MOs by >15%. Combined with >1,900 curated MO-species associations, we characterize MO motif distributions, presenting an exhaustive overview of MO biodiversity.

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“…Several structures, such as Neu5Acα2-3Galα1-3Galβ1-4Glc ( Supplementary Dataset 1 , slide 47), have, to our knowledge, never been described as a MO and represents a new glycan sequence, sialyl-α3Gl. Other bovines, such as Addax nasomaculatus ( 44 ), Bos taurus ( 17 , 45 ), or Bubalus bubalis ( 13 ), share characteristics such as extended sialic acids, usage of Neu5Gc, and lactosamine-based MOs, supporting their conservation in this family.…”

Section: Resultsmentioning

confidence: 98%

Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc

Jin,

Lundstrøm,

Korhonen

et al. 2023

Molecular & Cellular Proteomics

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Identification of sialyl oligosaccharides including an oligosaccharide nucleotide in colostrum of an addax (Addax nasomaculatus) (Subfamily Antelopinae)

Cited by 8 publications

References 22 publications

Characterization of Bioactive Sialyl Oligosaccharides Separated from Colostrum of Indonesia Dairy Goat

Characterization of Bioactive Sialyl Oligosaccharides Separated from Colostrum of Indonesia Dairy Goat

Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc

Breast Milk Oligosaccharides Contain Immunomodulatory Glucuronic Acid and LacdiNAc

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