Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer
Laura F. Dagley,
Jumana Yousef,
Adele Preaudet
et al.
Abstract:There are a limited number of clinically useful serum biomarkers to predict tumor onset or treatment response in gastric cancer (GC). For this reason, we explored the serum proteome of the gp130Y757F murine model of intestinal-type gastric cancer (IGC). We identified 30 proteins with significantly elevated expression in early gp130Y757F IGC and 12 proteins that were significantly elevated in late gp130Y757F IGC compared to age- and gender-matched wild-type mice. Within these signatures, there was an overlap of… Show more
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