Identification of self-renewing myoblasts in the progeny of single human muscle satellite cells

Baroffio, Anne; Hamann, Martine; Bernheim, Laurent; Bochaton‐Piallat, Marie‐Luce; Gabbiani, Giulio; Bader, Charles

doi:10.1046/j.1432-0436.1996.6010047.x

Cited by 154 publications

(110 citation statements)

References 39 publications

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“…Furthermore, recent studies have reported that these cells may exist in skeletal muscle. 7,9,[23][24][25][26][27][28][29] The presence of stem cells in skeletal muscle makes this tissue an attractive source of cells that are capable of enhancing the healing of various tissues. 9 In fact, we have recently observed that the genetic engineering of MDC (mc13) to express rhBMP-2 can be used to enhance closure of a non-healing skull defect.…”

Section: Discussionmentioning

confidence: 99%

“…23 It is now well established that muscle satellite cells are heterogenous and that skeletal muscle tissue may be a source for pluripotent stem cells. 7,9,[24][25][26][27][28][29] In particular, stem cell populations from muscle were recently shown to reconstitute the hematopoietic compartment of lethally irradiated mice and to partially restore the expression of dystrophin in the mdx mouse, an animal model of Duchenne muscular dystrophy. 7 In our laboratory, we have shown that the population of MDC (pp6) was, in fact, multipotent and had the capability of differentiating into other mesenchymal tissues, such as osteogenic lineage.…”

Section: Introductionmentioning

confidence: 99%

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Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction

et al. 2002

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction

et al. 2002

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“…Human self-renewing myoblasts have also been identiof primary myoblast isolation, have been understood. Transplanted autologous myoblasts can survive and fuse fied in the progeny of single human muscle satellite cells (HMSC) in culture (4). Native desmin-positive HMSC, with myofibers in vivo in syngeneic hosts; however, implanted cells were completely eliminated within 3 weeks cultured as single cells, yielded two major populations of myoblasts, alpha-sarcomeric (alpha-SR) actin-posiin allogeneic hosts.…”

Section: Introductionmentioning

confidence: 99%

Myoblast Therapy: From Bench to Bedside

Liu

Chen

2006

Cell Transplant

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Myoblasts are defined as stem cells containing skeletal muscle cell precursors. A decade of experimental work has revealed many properties of myoblasts, including the stability of resulting hybrid myofibers without immune suppression, the persistence of transgene expression, and the lack of tumorigenicity. Early phase clinical trials also showed that myoblast-based therapy is a promising approach for many intractable clinical conditions, including both muscle-related and non-muscle-related diseases. The potential application of myoblast therapy may be in the treatment of genetic muscle diseases, cardiomyocyte damaged heart diseases, and urinary incontinence. This review will provide an overview of myoblast biology, along with discussion of the potential application in clinical medicine. In addition, problems in current myoblast therapy and possible future improvements will be addressed.

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“…In the postnatal skeletal muscle tissue of growing rats, Schultz showed that approximately 80% of the satellite cell population is a highly proliferative population that is readily labelled by BrdU pulsing, whereas the remaining population divides slowly 40) . Subsequent reports described fastand slow-dividing cell populations among activated satellite cells in adult muscles 24,32,33,41) . However, there was no direct evidence regarding whether these two populations have such distinct roles during myogenic progression.…”

Section: Satellite Cell Heterogeneity Within Fibresmentioning

confidence: 99%

Satellite cell heterogeneity and hierarchy in skeletal muscle

Ono

2014

JPFSM

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Satellite cells are skeletal muscle tissue stem cells located between the basal lamina and sarcolemma of myofibres and play crucial roles in adult muscle repair and regeneration as well as postnatal muscle growth. More and more findings indicate that satellite cells exist as a genetically and functionally heterogeneous population among muscles, which is not only based on fibre types, but also embryonic origin. Satellite cells are also a heterogeneous population even within a single myofibre. Only a small population of satellite cells possesses "stemness" and exhibits remarkable regeneration with a high self-renewal ability when transplanted into injured muscles. Recent studies have shed light on the cellular and molecular characteristics of satellite cell heterogeneity including Pax7 + Myf5 -cells, satellite-side population cells, Pax7-nGFP high cells, and slow-dividing cells. Here, we review recent progress in our understanding of the heterogeneity and stem cell hierarchies in the satellite cell population.

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Identification of self-renewing myoblasts in the progeny of single human muscle satellite cells

Cited by 154 publications

References 39 publications

Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction

Muscle-derived cell-mediated ex vivo gene therapy for urological dysfunction

Myoblast Therapy: From Bench to Bedside

Satellite cell heterogeneity and hierarchy in skeletal muscle

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