Identification of roxarsonemetabolites produced in the system: Soil–chlorinated water–light by using HPLC-ICP-MS/ESI-MS, HPLC-ESI-MS/MS and High Resolution Mass Spectrometry (ESI-TOF-MS)

Arroyo‐Abad, Uriel; Mattusch, Jürgen; Möder, Monika; Elizalde-González, Marı́a P.; Wennrich, Rainer; Matysik, Frank‐Michael

doi:10.1039/c0ja00105h

Cited by 24 publications

(15 citation statements)

References 31 publications

(48 reference statements)

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“…In the solar radiation spectrum, roxarsone and nitarsone demonstrate some absorption; however, arsanilic acid and carbarsone exhibit minimal molar absorptivity above 300 nm. Photodegradation of organoarsenicals has been reported by a few authors Arroyo-Abad et al, 2011). Bednar et al (2003) reported photolytic degradation for roxarsone in deionized water (DI) at 250-400 nm (maximum emission at 300 nm).…”

Section: Photolytic Transformation Of Organoarsenicals In Watermentioning

confidence: 98%

“…HPLC-ICP- MS methods have been employed due to low detection limits in complex sample matrices (Ogra, 2012); however, these methods are of limited use when unknown, or unidentified, arsenic-containing species are present in solution. For this reason, development of LC-ESI-MS/MS methods is needed to ensure accurate quantification of organoarsenicals and the associated degradation products formed in environmental systems Arroyo-Abad et al, 2011). Development of such methods will allow greater characterization of arsenic-containing molecules formed through organoarsenical degradation in the environment.…”

Section: Analytical Measurement Of Organoarsenicalsmentioning

confidence: 99%

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Organoarsenicals in poultry litter: Detection, fate, and toxicity

Mangalgiri

Adak

Blaney

2015

Environment International

147

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Section: Photolytic Transformation Of Organoarsenicals In Watermentioning

confidence: 98%

Section: Analytical Measurement Of Organoarsenicalsmentioning

confidence: 99%

Organoarsenicals in poultry litter: Detection, fate, and toxicity

Mangalgiri

Adak

Blaney

2015

Environment International

147

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“…Dionex AS16 and AS7 columns can well separate ROX and p-ASA from the more common and more toxic As species including As(III), As(V) , MMA and DMA [27]. By using HPLC-ICP-MS and HPLC-ESI-MS/MS, chlorinated phenylarsonic acids and phenylarsine oxide derivatives were indentified in chlorine-containing water [26]. Under visible light, ROX can be decomposed to more toxic inorganic arsenic [26].…”

Section: Speciation Of Asmentioning

confidence: 99%

“…By using HPLC-ICP-MS and HPLC-ESI-MS/MS, chlorinated phenylarsonic acids and phenylarsine oxide derivatives were indentified in chlorine-containing water [26]. Under visible light, ROX can be decomposed to more toxic inorganic arsenic [26]. Poultry feather meal contains high concentration of inorganic As (30-1500 µg kg -1 ) (account for 37%-83% of total As) [28], possibly as the result of metabolism of organic arsenic feed additives.…”

Section: Speciation Of Asmentioning

confidence: 99%

“…4-Hydroxy-3-nitrobenzenearsenic acid (roxarsone, ROX) and 4-aminophenyl arsenic acid (p-arsanilic acid, p-ASA) have been widely used as coccidiosis prevention and animal growth promotion in the poultry and swine industry [26]. Development of chromatographic method to simultaneously monitoring ROX, p-ASA and their more toxic As metabolites is urgent for food safety and for evaluating the environmental impact of poultry litter application.…”

Section: Speciation Of Asmentioning

confidence: 99%

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Recent advances in speciation analysis of mercury, arsenic and selenium

2012

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Mercury (Hg), arsenic (As) and selenium (Se) are ubiquitous in the environment and exist in a variety of species, which have great influence on their transport, bioaccumulation and toxicity. This review presents the recent research progress in speciation analysis of Hg, As, and Se, with emphasis on enhanced cold vapor generation as interface for liquid chromatography and atomic spectrometry, speciation of volatile species in gas phase, and isotope dilution technique to improve the precision and accuracy of speciation. Hyphenated techniques to characterize the complexes of Hg and As with phytochelatins and chromatographic separation coupled with multi-collector-inductively coupled plasma mass spectrometry to measure species-specific isotopic ratios, are also briefly discussed. Mercury (Hg) and arsenic (As) are among the most highly toxic elements for humans and ecosystems and can cause serious environmental and human health problems even at low concentrations [1,2]. Selenium (Se) is an "essential toxin" for human health. It has been recognized as an important antioxidant and anti-cancer element. However, Se can also pose negative impact such as defective skin and hair loss [3]. The adsorption/uptake, transport, bioaccumulation, metabolism and toxicity of these elements strongly depend on their chemical species present in environmental and biological samples. In the environment, one species can transform to another through chemical or biological processes. For example, in anaerobic sediments, sulfur-reducing or iron-reducing bacteria can methylate inorganic mercury into highly toxic methylmercury (MeHg) [4,5]. Therefore, speciation analysis of Hg, As and Se is of great importance in order to elucidate the biogeochemcal cycle and toxicology of these elements. Speciation analysis mainly involves chromatographic separation (gas chromatography (GC) or high performance liquid chromatography (HPLC)) hyphenated with element-specific spectrometry or molecular mass spectrometry. This review presents the recent advances in speciation analysis of Hg, As, and Se based on chromatographic separation, with emphasis on enhanced cold vapor generation (CVG) as interface for LC and atomic spectrometry, speciation of volatile Hg, As and Se in gas phase, and isotope dilution technique to improve the precision and accuracy of speciation. Hyphenated techniques to characterize the complexes of Hg and As with phytochelatins and chromatographic separation coupled with multi-collector-inductively coupled plasma mass spectrometry (MC-ICP-MS) to measure species-specific isotopic ratios, are also briefly introduced.

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Ferrisilicalite‐1 Zeolite Monolith‐Based Affinitive Recognition of Intracellular Phosphorylated Protein Alteration in Tetrahymena thermophila Exposed to Photodegradates of Roxarsone and p‐Arsanilic Acid

Zhang

Han

et al. 2014

CLEAN Soil Air Water

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Research ArticleFerrisilicalite-1 Zeolite Monolith-Based Affinitive Recognition of Intracellular Phosphorylated Protein Alteration in Tetrahymena thermophila Exposed to Photodegradates of Roxarsone and p-Arsanilic AcidIn this study, heteroatomic ferrisilicalite-1 zeolite monolith (FS-1 ZM) was developed for affinitive recognition of intracellular phosphorylated protein in Tetrahymena thermophila after exposure to organoarsenic feed additives (roxarsone, ROX; p-arsanilic acid, PASA) and their photodegradates. ROX or PASA can be photodegradated into toxic inorganic arsenicals, which has become a public concern. After T. thermophila being exposed to ROX or PASA and their photodegradates, it is of significance to address intracellular protein phosphorylation alteration. However, it is challenging for effective capture of phosphorylated protein under the interference of arsenicals uptake. Followed by ferrisilicalite-1 zeolite monolith based immobilization process, sodium dodecyl sulfatepolyacrylamide electrophoresis, in-gel enzymatic digestion, and subsequent LC-MS/MS methodology, the integrated protocol was firstly attempted for identification of arsenicinduced phosphorylated protein alteration. It was found there was little impact of ROX or PASA on intracellular phosphorylated protein distribution. Alternatively, phosphorylated 14-3-3e was down-regulated after the cells were exposed to photodegradates of ROX or PASA, which were similar to those following exposure to inorganic arsenicals. Overall, inorganic arsenicals present during the degradative pathways of ROX or PASA affect the signal transduction system of T. thermophila cells. The down-regulation of phosphorylated 14-3-3e would be further studied as potential biomarker for organoarsenicals released into the environment.Abbreviations: ABS, acetate buffer solution; BSA, bovine serum albumin; FS-1 ZM, ferrisilicalite-1 zeolite monolith; HG-AFS, hydride generationatomic fluorescence spectrometry method; HSP, heat shock protein; iAs III , inorganic arsenite; iAs V , inorganic arsenate; IMAC, immobilized metal-affinity chromatography; MAPK, mitogen-activated protein kinases; PASA, p-arsanilic acid; PBS, phosphate buffered saline; PTM, post-translational modification; ROX, roxarsone; SDS-PAGE, sodium dodecyl sulfate-polyacrylamide electrophoresis; SEM, scanning electron microscopy

show abstract

Identification of roxarsonemetabolites produced in the system: Soil–chlorinated water–light by using HPLC-ICP-MS/ESI-MS, HPLC-ESI-MS/MS and High Resolution Mass Spectrometry (ESI-TOF-MS)

Cited by 24 publications

References 31 publications

Organoarsenicals in poultry litter: Detection, fate, and toxicity

Organoarsenicals in poultry litter: Detection, fate, and toxicity

Recent advances in speciation analysis of mercury, arsenic and selenium

Ferrisilicalite‐1 Zeolite Monolith‐Based Affinitive Recognition of Intracellular Phosphorylated Protein Alteration in Tetrahymena thermophila Exposed to Photodegradates of Roxarsone and p‐Arsanilic Acid

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