Identification of Rosellinia species as producers of cyclodepsipeptide PF1022 A and resurrection of the genus Dematophora as inferred from polythetic taxonomy

Recent progress in biodiversity research on the Xylariales and their secondary metabolism

“…to study its production in planta using quantitative PCR and transcriptomics and shed some light on the natural function of the molecule. The life cycle of the producer of the cyclodepsipeptide "PF-1022A" (83) [115] has also recently been elucidated in the course of the abovementioned study that also resulted in the segregation of the plant-pathogenic genus Dematophora from Rosellinia [8]. This compound is up-to-date the only one derived from an endophytic fungus that was further developed into a marketed drug.…”

“…Besides Xylaria , only for some genera of the Xylariaceae novel secondary metabolites have been described in the past 3 years. Those included Nemania , Rosellinia , and Dematophora , the latter of which has recently been resurrected and emended [ 8 ]. Most other genera, even larger ones like Hypocopra and Kretzschmaria , are nearly untapped concerning their secondary metabolites.…”

“…Species of Dematophora were up to recently included in the genus Rosellinia , but were segregated due to differing asexual morphs and a well-defined clade in phylogenetic analyses [ 8 ]. The same paper also described two novel bioactive isopimarene diterpenoids from D. bunodes , (previously known as R. bunodes ) named dematophoranes A ( 3 ) and B.…”

“…Thereby, S. phoenix was placed close to the coprophilous genera like Poronia and Podosordaria within the Xylariaceae. Complementarily, a screening of its secondary metabolites revealed two novel eremophilane sesquiterpenoids named phoenixilanes A (8) and B, which were found devoid of promising bioactivities in antimicrobial and cytotoxicity assays. Besides, several chemotaxonomically meaningful metabolites were isolated, e.g., punctaporonin B, known from Poronia spp., and 8,9-dehydroxylarone, reported from a Xylaria sp., thereby confirming the phylogenetic classification to the Xylariaceae [23].…”

Taxonomic Re-Examination of Nine Rosellinia Types (Ascomycota, Xylariales) Stored in the Saccardo Mycological Collection

“…They occur in temperate and tropical regions as saprobes, some as endophytes and a few as root pathogens of economic important plant species (e.g., Vitis vinifera ), growing mainly on deciduous woods of dicotyledonous plants [ 2 ]. Rosellinia species have a geniculosporium-like asexual morph and rarely a nodulisporium-like stages [ 3 , 4 ]. Over time, Rosellinia was synonymized with other genera (e.g., Dematophora ) and placed in different families until Miller in 1928 [ 5 ] considered it as a genus of the family Xylariaceae, a classification now also confirmed by phylogenetic studies [ 4 , 6 ].…”