Identification of risk factors on secondary hyperparathyroidism undergoing long-term haemodialysis with vitamin D3

Background. Renal hyperparathyroidism (RHPT) is a serious complication of long-term dialysis treatment. Two intervention methods can be administered to treat RHPT, namely percutaneous ethanol injection therapy (PEIT) and a parathyroidectomy (PTx). PEIT is associated with a significant adverse event, adhesion formation. This study was performed to investigate the effect of PEIT on subsequent PTx.Methods. A total of 80 subjects were included in the study. The patients had a diagnosis of RHPT for which surgery was indicated. They were divided according to whether they underwent PEIT (PEIT group) or not (non-PEIT group). The outcomes of PTx following PEIT were evaluated.Results. There were 19 patients in the PEIT group and 61 in the non-PEIT group. The operation time was significantly longer in the PEIT group but no significant differences in the amount of bleeding or frequency of recurrent nerve paralysis were observed. The intact PTH levels immediately following surgery were slightly higher in the PEIT group. The postoperative intact PTH levels were found to be significantly higher in those who received two or more courses of PEIT. The number of patients with an intact PTH level >60 pg/ml on postoperative Day 1 was significantly higher in the PEIT group.Conclusions. These findings suggested that PEIT prior to PTx can affect the subsequent surgical outcome due to associated adhesions and dissemination. For patients with a possibility of either a decreased efficacy or a lack of efficacy for PEIT, it is therefore important to consider PTx from the very beginning of the treatment.

show abstract

Effects of percutaneous ethanol injection therapy on subsequent surgical parathyroidectomy

Nakamura

Marui

Ubara

et al. 2008

Clinical Kidney Journal

View full text Add to dashboard Cite

show abstract

Considerations for the treatment of secondary hyperparathyroidism in renal failure.

Felsenfeld

1997

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Surgical treatment of secondary hyperparathyroidism in patients with chronic kidney disease

Pisarenka

2019

Vescì Nac. akad. navuk Belarusì, Ser. med. navuk

View full text Add to dashboard Cite

Surgery of patients with secondary hyperparathyroidism in the era of calcimimetics continues to play an important role in selected patients and achieves an efficient control of hyperparathyroidism. Taken together, the results of literature review suggest a clinically significant beneficial effect of surgical parathyroidectomy to decrease the overall and cardiovascular mortality in patients with secondary hyperparathyroidism due to chronic kidney disease. However, the independent randomized controlled trial comparing surgery with medical therapy to clarify the outcome and to improve the quality of life is in need.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Identification of risk factors on secondary hyperparathyroidism undergoing long-term haemodialysis with vitamin D3

Cited by 10 publications

References 0 publications

Effects of percutaneous ethanol injection therapy on subsequent surgical parathyroidectomy

Effects of percutaneous ethanol injection therapy on subsequent surgical parathyroidectomy

Considerations for the treatment of secondary hyperparathyroidism in renal failure.

Surgical treatment of secondary hyperparathyroidism in patients with chronic kidney disease

Contact Info

Product

Resources

About