Identification of risk factors for the prognosis of Chinese patients with endometrial carcinoma

Abstract

This study aimed to retrospectively analyze risk factors for the prognosis of Chinese patients with endometrial carcinoma. Total 600 patients who were admitted to the Department of Gynecology, the Fourth Hospital of Hebei Medical University and were pathologically diagnosed as endometrial carcinoma after surgery from January 1, 1997 to December 31, 2006 were selected, and the related factors affecting their prognosis were analyzed. The survival of 600 patients with endometrial carcinoma was 2 to 136.5 months (average survival 57.39 ± 33.55 months), and 109 cases (18.2%) died from endometrial cancer. The overall survival rate of 1, 3, and 5 years after surgery was 96.8%, 89.9%, and 82.1%, respectively. Univariate analysis showed that age, menopausal status, pathological type, histological grade, pathological staging, tumor size, myometrial invasion, cervical involvement, ovarian metastasis, lymph node metastasis, and treatment method were the factors affecting the prognosis of endometrial carcinoma. Multivariate regression analysis showed that pathological type, histological grade, pathological staging, and cervical involvement were independent risk factors for the prognosis of endometrial carcinoma. The patients with high-grade and deep myometrial invasion, cervical involvement, full cavity tumor, and lymph node metastasis had a high incidence of ovarian metastasis. Pathological type, histological grade, pathological staging, and cervical involvement are independent risk factors affecting the prognosis of Chinese patients with endometrial carcinoma.

Evaluating the Prognostic Factors and Survival Rates of Endometrial Cancer Patients in a Tertiary Referral Hospital in Northeast Thailand

“…Furthermore, our result showed that the patients with endometrioid histopathology (80.02%) exhibited a higher 5-year survival rate than non-endometrioid group. These findings are in line with previous research conducted in Thailand (79.6%) [ 14 ] and China (85.2%) [ 23 ]. On the contrary, non-endometrioid histopathology may be associated with a higher mortality rate due to the aggressive nature of these tumor subtypes [ 28 ].…”

“…Specifically, the highest 5-year survival rate was observed among patients aged less than 45 years (88.62%), while the lowest rate was seen in those aged ≥60 (68.63%). These results align with previous research conducted in different countries, including China [ 23 ] and Malaysia [ 20 ]. The 5- and 10-year survival rates within the youngest age groups have consistently maintained a high level throughout the entire study period, consistent with findings from research conducted in Sweden [ 25 ].…”

“…As well, our study found that patients diagnosed with stage I EC displayed the highest 5-year survival rate (87.45%). These findings align with research conducted in China (90.9%) [ 23 ], the Netherlands (86.3%) [ 27 ], and Thailand (91.6%) [ 14 ]. Together, these findings strongly emphasize that patients diagnosed with advanced stages of EC tend to have significantly lower chances of survival than those diagnosed at an early stage.…”

“…This rate closely paralleled the findings of a 2015 study involving European women diagnosed with EC (76%) [21]. However, it was lower than the 5-year survival rates reported in studies conducted in Japan (96.4%) [22], Korea (89.0%) [5], China (82.1%) [23], and developed countries (80%) [24]. In this study, the 10-year survival rate was determined to be 67.86%, which was lower than the rates reported in studies conducted in Sweden (80.70%) [25].…”

“…Moreover, our recent study revealed that the five-year overall survival rate of EC patients who underwent surgery alone was 82.72%. This result was higher than research conducted in China (76.5%) [ 23 ] but were lower than the figures reported for Korea (95.2%) Korea (95.2%) [ 5 ]. This higher survival rate for surgery patients can be attributed to surgery being the primary and one of the most effective treatments for EC [ 29 ].…”