Identification of risk factors associated with nosocomial infection by rotavirus P4G2, in a neonatal unit of a tertiary-care hospital

Herruzo, Rafael; Omeñaca, F; García, Sara; Díez, Jesús; Sánchez-Fauquier, Alicia

doi:10.1111/j.1469-0691.2008.02667.x

Cited by 28 publications

(18 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These figures were much lower than the rate of nosocomial infection reported in local studies performed in Spain, in which 5.0% of hospitalized children up to two years of age were infected with nosocomial rotavirus 5 (0.66% in our study) and 7.4% of newborns admitted became infected. 7 Other nosocomial infections, such as Acinetobacter baumanii, present rates of infection more similar to those found for rotavirus in this study (0.82 cases per 100 admissions). 12 When comparing local studies performed in other WHO European Region countries, significant variation in nosocomial rotavirus incidence rate can be found, from 1% of all admissions in Israel or 1.9% in Italy to 13.9% in France.…”

Section: Discussionsupporting

confidence: 67%

See 1 more Smart Citation

Hospital-acquired rotavirus infections in Spain over a ten-year period (1998-2007)

Gil-Prieto¹,

M²,

Al³

et al. 2009

Human Vaccines

View full text Add to dashboard Cite

IntroductionAcute gastroenteritis poses an important health problem in developing countries and a considerable economic burden in developed countries, taking into account not only direct costs but also indirect costs, such us days of work lost by parents. 1,2 Rotavirus is regarded as the most frequent cause of acute gastroenteritis, with 3.6 million cases per year in children up to five years of age in Europe, 3,4 and it imposes a median hospitalization cost of 1,417 Euros among EU-25 Member States.Rotavirus can survive for weeks in water and on different surfaces. Thus, it is easily transmitted through contaminated surfaces, particularly in kindergartens and pediatric units in hospitals. Hygienic preventive measures are not effective in stopping transmission, hence the high morbidity in developed countries.Real incidence of rotavirus infection is underestimated because there is not a specific epidemiological surveillance system. It is estimated that a significant percentage (20 to 60%) of hospital admissions due to acute diarrhea in children are caused by rotavirus, most of these in children younger than six months. Although rotavirusrelated mortality in developed countries is low, the morbidity and associated consumption of health care resources are considered to be high. 5Gastrointestinal infections, especially those caused by rotavirus, are considered among the most frequent cause of nosocomial infection in pediatric units. In contrast to community-acquired rotavirus, nosocomial infections mainly affect breast-fed babies under six months of age.5 Symptoms appear two to six days after hospitalization. A high percentage of non-symptomatic carriers contribute to spread of the infection. The risk of nosocomial infection is associated with lengthy hospitalizations, low birth weight, presence of chronic pathology, immunocompromise and malnutrition. [5][6][7] This study was performed to assess the burden of nosocomial rotavirus infection in Spain during a 10-year period. ResultsA total of 10,990 cases of rotavirus disease (ICD 9 CM codes 008.61; secondary diagnosis position) in hospitalized children five years of age and younger were reported during the 10-year Hospital-acquired rotavirus infections in spain over a ten-year period (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007) Ruth Gil-prieto, Background and objectives: To analyze the epidemiology and burden of rotavirus infections amongst hospitalized children up to 5 years of age in spain over a 10-year period (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007).Results: During the study period (1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007), a total of 10,990 cases of rotavirus disease mentioned as a secondary diagnosis were recorded (annual incidence of 59.02 cases per 100,000 people and 0.45 cases per 100 admissions). The average patient age was 9.8 months (sD 9.3), with 71% of the patients younger than 12 months of age. The mortality rate for children hospitalized for other primary causes, with rotavirus gastroenteritis as a...

show abstract

Section: Discussionsupporting

confidence: 67%

“…The risk of nosocomial infection is associated with lengthy hospitalizations, low birth weight, presence of chronic pathology, immunocompromise and malnutrition. [5][6][7] This study was performed to assess the burden of nosocomial rotavirus infection in Spain during a 10-year period. …”

mentioning

confidence: 99%

Hospital-acquired rotavirus infections in Spain over a ten-year period (1998-2007)

Gil-Prieto¹,

M²,

Al³

et al. 2009

Human Vaccines

View full text Add to dashboard Cite

show abstract

“…In addition, several reports have described the association of NEC with RV infection or colonization [7][8][9]. In our cohort we found two patients with RV infection and NEC.…”

Section: Case Definitions and Laboratory Methods: Nec Was Staged Accosupporting

confidence: 48%

“…In contrast to the usually self-limiting course of GE in healthy children, NEC, a major and life-threatening gastrointestinal emergency, has occasionally been reported associated with RV infection or colonization in preterm infants [7][8][9]. Moreover, we have previously shown that colonization or infection with HAstV may also be associated with severe confirmed NEC in preterm infants [10], and recently, Armbrust et al [11] reported a NV outbreak in 11 premature infants in a tertiary Neonatal Intensive Care…”

Section: Answermentioning

confidence: 99%

Clinical characteristics of viral intestinal infection in preterm and term neonates

Bağcı

Eis‐Hübinger

Yassin

et al. 2010

Eur J Clin Microbiol Infect Dis

View full text Add to dashboard Cite

Objectives: The clinical presentation of the viral enteric pathogens in newborn infants has not been adequately examined. The aim of this study was to evaluate the clinical characteristics of viral intestinal infections in newborn infants. Methods: Clinical data of all term and preterm infants admitted to our tertiary neonatal intensive care unit from 1998 to 2007 with clinical signs of gastroenteritis (GE) or necrotizing enterocolitis (NEC) were retrospectively reviewed and compared between infants with different viral enteric pathogens in stool specimens. Results: In thirty-four infants with signs of GE or NEC, enteropathogenic viruses were found in stool specimens. Rotavirus was detected in 12 cases, of which 2 infants had NEC. Compared with infants with rotavirus or norovirus, infants with astrovirus more frequently suffered from NEC (p<0.05). In addition, an acute systemic inflammatory response was significantly more common in patients with astrovirus infection (astrovirus vs. rotavirus and astrovirus vs. norovirus p<0.01 and p<0.05, respectively). Of 8 children infected with norovirus, one infant had a systemic acute inflammatory response and NEC. Conclusions: This study demonstrates that in newborn infants, intestinal rotavirus, norovirus, and astrovirus infections may be associated with severe illness such as hemorrhagic enteritis resulting in bloody diarrhea or even NEC. We revised our manuscript "Clinical characteristics of viral intestinal infection in preterm and term neonates" according to the reviewers' comments. You may find our comments, additions and answers below (all changes made to the manuscript text are underlined).Reviewers' Comment 1: In the Abstract, under the Objectives paragraph it is stated that "The clinical presentation of viral intestinal infections in preterm and term neonates has not been adequately evaluated". This statement is not an objective in itself. It is an observation that could be included as background or as part of the introduction. The aims of the study should be better defined. Answer 1: According the reviewers' suggestions we revised the objectives in the abstract. Because of "200 words-limit in abstract" we revised the abstract, too (all changes made to the manuscript text are underlined).Reviewers' Comment 2: In the Results section (p.2, line 19) it should be mentioned that enteropathogenic viruses were found in 34 infants out of 220 (15.45%) infants with gastroenteritis (GE) and NEC (nectotizing enterocolitis). Answer 2: According the reviewers' suggestions we changed the sentence as recommended (Page 6, p.2).Reviewers' Comment 3: Among 112 infants with gastroenteritis, enteric viruses were detected in 22 patients (19.64%), and in 12 cases (11.11%) out of 108 infants with NEC. That means that approximately only in one case out of every 10 infants suffering of NEC was an enteric virus detected. The majority of cases with RV infection (10/12) were mild and self-limiting GE, but 2 preterm infants had signs of NEC. In this study, no enteric viruses were de...

show abstract

“…As gut bacteria may play an important role in disease pathogenesis, current animal models of NEC use intraluminal bacteria to disrupt the intestinal mucosa and activate an inflammatory cascade leading to necrosis (3). Several studies suggest that rotavirus in combination with other microorganisms can increase the intestinal vulnerability to bacterial invasion, leading to an exaggerated intestinal immune response, and therefore cause NEC (4)(5)(6)(7). Moreover, clinical reports indicate that the colonization or infection with astro-, toro-, or norovirus have an impact on NEC severity in preterm infants (8)(9)(10)(11).…”

mentioning

confidence: 99%

The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice

Ginzel

Klemann

et al. 2015

Pediatr Res

View full text Add to dashboard Cite

Background: Necrotizing enterocolitis (NEC) is a lifethreatening gastrointestinal disease in premature infants with high mortality and morbidity with uncertain pathogenesis. Recent research focused on the role of intraluminal bacteria and lipopolysaccharide (LPS). However, an additional role of viral agents in the pathogenesis of NEC has recently been postulated. We assessed the role of polyinosinic:polycytidylic acid (pIC) mimicking viral dsRNA in contributing to the development of NEC in neonatal mice. Methods: Four-d-old C57BL/6J pups were stressed by asphyxia and hypothermia twice daily. Animals were either fed by formula only (FO), formula containing LPS or pIC. After 72 h, mice were euthanized, intestines harvested, and the severity of NEC was assessed. results: Breastfed mice showed no evidence of NEC. Very mild NEC-like lesions were observed in mice fed by FO. Supplementation of LPS or pIC to the formula led to increased intestinal tissue damage and inflammation compared with FO in a similar manner. conclusion: Our study demonstrates the ability of viral factors to induce NEC in neonatal mice even in the absence of LPS. Furthermore, we present a new mouse model of pIC-induced NEC which may be used to obtain further mechanistic insights in the pathogenesis of this disease.

show abstract

Identification of risk factors associated with nosocomial infection by rotavirus P4G2, in a neonatal unit of a tertiary-care hospital

Cited by 28 publications

References 26 publications

Hospital-acquired rotavirus infections in Spain over a ten-year period (1998-2007)

Hospital-acquired rotavirus infections in Spain over a ten-year period (1998-2007)

Clinical characteristics of viral intestinal infection in preterm and term neonates

The viral dsRNA analogue poly (I:C) induces necrotizing enterocolitis in neonatal mice

Contact Info

Product

Resources

About