Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

Wang, Mingdong; Little, Julian; Gomes, James; Cashman, Neil R.; Krewski, Daniel

doi:10.1016/j.neuro.2016.06.015

Cited by 176 publications

(158 citation statements)

References 296 publications

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“…Traumatic injury acted as effect modifier in that study: those who were not physically active, but did experience traumatic injuries, were at risk of developing ALS. As history of trauma has been associated with an increased risk of ALS in some studies,37 a possible role of trauma as a risk factor cannot be entirely excluded. However, adjusting for ever having experienced a traumatic injury in our study did not change the odds ratios for PA (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

Visser

Rooney

D’Ovidio

et al. 2018

J Neurol Neurosurg Psychiatry

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Section: Discussionmentioning

confidence: 99%

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

Visser

Rooney

D’Ovidio

et al. 2018

J Neurol Neurosurg Psychiatry

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“…There is mixed evidence for the involvement of chemicals, such as heavy metals, ambient aromatic hydrocarbons, pesticides, and cyanotoxins 99– 103 . Trauma, including head injury, also appears to be a risk factor in meta-analysis 104 .…”

Section: Environmental Risk Factorsmentioning

confidence: 99%

What causes amyotrophic lateral sclerosis?

2017

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Amyotrophic lateral sclerosis is a neurodegenerative disease predominantly affecting upper and lower motor neurons, resulting in progressive paralysis and death from respiratory failure within 2 to 3 years. The peak age of onset is 55 to 70 years, with a male predominance. The causes of amyotrophic lateral sclerosis are only partly known, but they include some environmental risk factors as well as several genes that have been identified as harbouring disease-associated variation. Here we review the nature, epidemiology, genetic associations, and environmental exposures associated with amyotrophic lateral sclerosis.

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“…Through these disruption pathways and increased susceptibility to environmental insults, Pb could play a part in substantially increasing the risk of neurological disorders such as ALS, with epidemiological evidence in other neurodegenerative diseases and cognitive function supporting this association 5 10 11. Some meta-analyses have suggested that exposure to Pb and other heavy metals may be a risk factor for ALS 12. Additionally, increased risk of ALS has been observed in certain occupations with high exposure to Pb, including construction workers,13 14 military servicemen15 16 and mechanics 17 18…”

Section: Introductionmentioning

confidence: 99%

Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark

et al. 2019

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ObjectivesPrevious research has indicated links between lead (Pb) exposure and increased risk of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS). In this study, we evaluated the association between occupational Pb exposures and ALS.MethodsALS cases were ascertained through the Danish National Patient Registry from 1982 to 2013 and age and sex-matched to 100 controls. Using complete employment history since 1964 from the Danish Pension Fund, cumulative Pb exposure was estimated for each subject via a Danish job exposure matrix. Associations were evaluated using conditional logistic regression analyses and stratified by sex.ResultsFor men with >50% probability of exposure, there was an increase in odds of ALS for exposures in the 60th percentile or higher during any time 5 years prior to diagnosis (aOR: 1.35; 95% CI 1.04 to 1.76) and 10 years prior to diagnosis (aOR: 1.33; 95% CI 1.03 to 1.72). No significant associations were observed in women, and there were no linear trends seen for Pb exposures for either sex.ConclusionsOur study indicates an association between consistently higher occupational Pb exposures and ALS. These findings support those of previously reported associations between ALS and specific occupations that commonly experience Pb exposure.

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Identification of risk factors associated with onset and progression of amyotrophic lateral sclerosis using systematic review and meta-analysis

Cited by 176 publications

References 296 publications

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

What causes amyotrophic lateral sclerosis?

Population-based study of amyotrophic lateral sclerosis and occupational lead exposure in Denmark

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