Identification of risk factors affecting impaired glucose metabolism among the adult population of district Srinagar

Saleem, Sheikh Mohd; Jan, Shah Sumaya; Haq, Inaamul; Khan, S. Muhammad Salim

doi:10.1016/j.dsx.2019.01.023

Cited by 8 publications

(3 citation statements)

References 19 publications

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“…The second cohort (88 PWH) comprised PWH with normal blood glucose, de ned as having both FBG of < 100mg/dl and a 2hBG of < 140mg/dl at baseline. The cohorts were matched for sex and exact or nearest age and baseline body mass index, factors known to affect glucose metabolism[28], [29] Outcomes The primary outcome for this analysis was change in mean fasting blood glucose from baseline to week 48 and 2-hour blood glucose from baseline to week 36, compared between PWH with pre-DM and those with normal blood glucose at baseline.…”

Section: Study Design and Settingmentioning

confidence: 99%

Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks

Mulindwa

Schwarz

Brusselaers

et al. 2023

Preprint

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Background: The Uganda ministry of Health recommends frequent blood glucose monitoring for the first six months on dolutegravir, in people with HIV (PWH) having pre-diabetes mellitus (pre-DM). We sought to determine if indeed PWH with pre-diabetes started on dolutegravir had worse blood glucose outcomes at 48 weeks compared to those with normal blood glucose. Methods: In this matched cohort study, we compared 44 PWH with pre-DM and 88 PWH with normal blood glucose at baseline. The primary outcome was change in mean fasting blood glucose (FBG) from baseline to week 48 and 2-hour blood glucose (2hBG) from baseline to week 36 compared between the two groups. Results: There was significant increase in FBG in PWH with normal blood glucose (mean change in FBG(FBG): 3.9mg/dl, 95% confidence interval (95% CI): (2.2, 5.7), p value (p) = < 0.0001) and decrease in those with pre-DM (FBG: -6.1mg/dl, 95%CI (-9.1, -3.2), p = < 0.0001) at 48 weeks. 2hBG at 36 weeks was significantly lower than at baseline in both groups with the magnitude of reduction larger in those with pre-DM at 12 weeks (adjusted differences in mean drop in 2hBG (a2hBG): -19.69mg/dl, 95%CI (-30.19, -9.19), p = < 0.0001) and 36 weeks (a2hBG: -19.97mg/dl, 95%CI (-30.56, -9.39), p = < 0.0001). Conclusion; We demonstrated that Ugandan ART naïve PWH with pre-diabetes at enrollment have consistent improvement in both fasting blood glucose and glucose tolerance over 48 weeks on dolutegravir. Intensified blood glucose monitoring of these patients in the first six months of dolutegravir may be unnecessary.

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Section: Study Design and Settingmentioning

confidence: 99%

Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks

Mulindwa

Schwarz

Brusselaers

et al. 2023

Preprint

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show abstract

“…По данным исследований, ФР нарушения метаболизма глюкозы включают в себя возраст, ожирение и более высокое потребление газированных напитков, гипертонию, курение, высококалорийную диету и положительную семейную историю диабета [27]. По сравнению с людьми с нормальной толерантностью к глюкозе, подростки и молодые люди с предиабетом имеют значительно более высокие уровни липопротеинов низкой плотности (ЛПНП), систолическое артериальное давление (АД), центральное ожирение и более низкую чувствительность к инсулину (р <0,05 для всех) [6].…”

Section: факторы риска и ассоциация с другими заболеваниямиunclassified

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

Пырикова

Осипова

Полякова

2020

Arhivʺ vnutrennej mediciny

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Prediabetes is a common violation of carbohydrate metabolism, the medical and social relevance of which is due to the negative impact on the incidence of type 2 diabetes mellitus (DM) and cardiovascular disease (CVD). The analyzed literature emphasizes the presence of a close pathogenetic relationship between type 2 DM/prediabetes and CVD. This relationship becomes even more relevant, taking into account, on the one hand, the persistent upward trend in the prevalence of carbohydrate metabolism disorders in the population, and on the other hand, the fact that in patients with dysglycemia it is cardiovascular complications that are the main cause of death. However, while the significance of type 2 DM as a risk factor for CVD is widely known and its presence immediately stratifies most patients to a group of high or very high cardiovascular risk, the contribution of prediabetes to the development of CVD remains underestimated among the therapeutic and cardiological communities. The high prevalence of prediabetes creates prerequisites for a further increase in the incidence of type 2 DM and CVD in the Russian Federation, which requires doctors of various specialties to be wary of early detection of prediabetes, since timely preventive measures can significantly reduce the risk of type 2 DM and its complications in the future. Currently, the effectiveness of both non-drug and drug strategies in preventing the development of type 2 DM in people with prediabetes has been confirmed, more and more data are accumulating about the possibility of effective prevention of CVD in prediabetes. According to modern research, the primary role of measures to actively change lifestyle in the treatment and prevention of prediabetes is emphasized, at the same time, the effectiveness of these measures can be reduced due to insufficient commitment of the patients themselves to their independent long-term implementation. Therefore, the strategy of prescribing metformin for the prevention of type 2 diabetes is absolutely justified if the doctor and patient recognize the inefficiency or inability to follow the recommendations for active lifestyle changes for a long time. The article presents the data on the etiology, epidemiology, diagnosis, and approaches to the management of patients with prediabetes from the standpoint of modern recommendations.

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“…The prevalence of diabetes, especially type 2, has increased significantly in recent decades (3) . Recent studies in Kashmir reported prevalence of 9.8 % of diabetes among adult population (4)(5) . Along with diabetes, the rate of complication such as atherosclerosis, retinopathy, nephropathy, peripheral neuropathy with the risk diabetic foot are also increasing (6) .…”

Section: Introductionmentioning

confidence: 99%

Status of Care and Control among diabetic patients in Central Kashmir: A Cross-sectional Study

Singh¹

2020

jmscr

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Background: Diabetes mellitus is one of those non-communicable diseases which has both immediate and delayed complications resulting in morbidity, high out of pocket costs, and high mortality rates. The objectives of our study was to assess the status of care and blood glucose control among patients with type 2 diabetic patients' in central Kashmir division. Materials and Methods: This was a cross-sectional study done among 53 diagnosed cases of type 2 diabetes, mellitus. The sample was selected through multi-stage cluster random sampling and data was collected through a questionnaire by interviewing patients and reviewing their files, and 3 categories of demographic, clinical and socio-economic factors were studied. The data was analyzed by Chi-Square test using SPSS software version 20. Results: The results of Chi-square test indicated that there is significant relationship between gender of the patients, increasing age among them, their marital status and level of education among them, while insignificant relationship was found for the occupation and family size of the diabetic patients. The results also showed significant relationship between body mass index, family history of diabetes, ordered drug use and nutritional education on diabetes. Socioeconomic characteristics of the studied samples regarding care and control showed significant relationship of smoking behavior and exercise with diabetes while insignificant results were concluded for vegetable consumption and income level. Conclusion:We concluded that life style modifications, dietary modifications, control of weight gain and self-care programs are an effective medium for prevention of complication of diabetes mellitus.

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Identification of risk factors affecting impaired glucose metabolism among the adult population of district Srinagar

Cited by 8 publications

References 19 publications

Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks

Blood glucose outcomes of anti-retroviral therapy naïve Ugandan people with HIV with pre-diabetes mellitus initiated on dolutegravir for 48 weeks

Modern Aspects of the Clinic, Diagnosis and Treatment of Prediabetes

Status of Care and Control among diabetic patients in Central Kashmir: A Cross-sectional Study

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