Identification of Rheumatoid Arthritis Patients With Vertebral Fractures Using Bone Mineral Density and Trabecular Bone Score

Bréban, Sophie; Briot, Karine; Kolta, Sami; Paternotte, Simon; Ghazi, M.; Fechtenbaum, J.; Roux, Christian

doi:10.1016/j.jocd.2012.01.007

Cited by 116 publications

(82 citation statements)

References 21 publications

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“…Over a mean six years of follow-up, TBS declined by 3.3% (p < 0.001), independent of the severity of spinal osteoarthritis. Conversely, though femoral neck and total hip aBMD also decreased over time and were not affected by osteoarthritis grade, there was no net decrease in lumbar aBMD, which was also associated with the grade of spinal arthritis [82].…”

Section: Osteoarthritismentioning

confidence: 78%

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice

Harvey

Glüer

Binkley

et al. 2015

Bone

386

255

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Trabecular bone score (TBS) is a recently-developed analytical tool that performs novel grey-level texture measurements on lumbar spine dual X-ray absorptiometry (DXA) images, and thereby captures information relating to trabecular microarchitecture. In order for TBS to usefully add to bone mineral density (BMD) and clinical risk factors in osteoporosis risk stratification, it must be independently associated with fracture risk, readily obtainable, and ideally, present a risk which is amenable to osteoporosis treatment. This paper summarizes a review of the scientific literature performed by a Working Group of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis. Low TBS is consistently associated with an increase in both prevalent and incident fractures that is partly independent of both clinical risk factors and areal BMD (aBMD) at the lumbar spine and proximal femur. More recently, TBS has been shown to have predictive value for fracture independent of fracture probabilities using the FRAX ® algorithm. Although TBS changes with osteoporosis treatment, the magnitude is less than that of aBMD of the spine, and it is not clear how change in TBS relates to fracture risk reduction. TBS (corresponding author post-publication: nch@mrc.soton.ac.uk. (corresponding author pre-publication: w.j.pontefract@sheffield.ac.uk). Europe PMC Funders Group Europe PMC Funders Author ManuscriptsEurope PMC Funders Author Manuscripts may also have a role in the assessment of fracture risk in some causes of secondary osteoporosis (e.g. diabetes, hyperparathyroidism and glucocorticoid-induced osteoporosis). In conclusion, there is a role for TBS in fracture risk assessment in combination with both aBMD and FRAX.

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Section: Osteoarthritismentioning

confidence: 78%

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice

Harvey

Glüer

Binkley

et al. 2015

Bone

386

255

View full text Add to dashboard Cite

show abstract

“…TBS is less expensive and more easily accessible than CT or MRI for wide-spread clinical implementation or as an outcome in large research studies. The very first TBS reports showed applications for the prediction of fracture risk in osteoporosis (39)(40)(41), have added value in those individuals with bone density outside of the osteoporosis range (42) and monitoring of treatment effects (43,44), and similarly, TBS may find an application in other conditions such as primary hyperparathyroidism (45), hypercortisolism (46), rheumatoid arthritis (47), and diabetes-related bone disease (48). A major advantage is that it can be derived from DXA scans using dedicated post-processing software.…”

Section: Dxa-additional Parametersmentioning

confidence: 99%

Quantitative imaging methods in osteoporosis

Oei

Koromani

Rivadeneira

et al. 2016

Quant. Imaging Med. Surg.

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“…A cross-sectional study evaluated 185 women (mean age 56 ± 14 years) known to have rheumatoid arthritis (RA) for 15.5 ± 9.9 years (38). Approximately 60% of the study population (n = 112) was in use of glucocorticoids (mean daily dose of 6.4 mg equivalent to prednisone).…”

Section: Rheumatoid Arthritismentioning

confidence: 99%

Trabecular bone score: perspectives of an imaging technology coming of age

Silva

Bilezikian

2014

Arq Bras Endocrinol Metab

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The trabecular bone score (TBS) is a new method to describe skeletal microarchitecture from the dual energy X-ray absorptiometry (DXA) image of the lumbar spine. While TBS is not a direct physical measurement of trabecular microarchitecture, it correlates with micro-computed tomography (µCT) measures of bone volume fraction, connectivity density, trabecular number, and trabecular separation, and with vertebral mechanical behavior in ex vivo studies. In human subjects, TBS has been shown to be associated with trabecular microarchitecture and bone strength by high resolution peripheral quantitative computed tomography (HRpQCT). Cross--sectional and prospective studies, involving a large number of subjects, have both shown that TBS is associated with vertebral, femoral neck, and other types of osteoporotic fractures in postmenopausal women. Data in men, while much less extensive, show similar findings. TBS is also associated with fragility fractures in subjects with secondary causes of osteoporosis, and preliminary data suggest that TBS might improve fracture prediction when incorporated in the fracture risk assessment system known as FRAX. In this article, we review recent advances that have helped to establish this new imaging technology. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Keywords Trabecular bone score; osteoporosis; fracture risk; bone mineral density; microarchitecture RESUMO TBS (do inglês, "trabecular bone score") é um novo método que estima a microarquitetura óssea a partir de uma imagem de densitometria óssea (DXA) da coluna lombar. Apesar de o TBS não ser uma medida física direta da microarquitetura trabecular, ele correlaciona-se com o volume ósseo, densidade da conectividade trabecular, número de trabéculas e separação trabecular medidos por microtomografia computadorizada (µCT), e com medidas mecânicas da resistência óssea vertebral em estudos ex vivo. Estudos em humanos confirmaram que o TBS associa-se a microarquitetura trabecular e resistência óssea medidas por tomografia computadorizada quantitativa periférica de alta resolução (HRpQCT). Estudos transversais e prospectivos, envolvendo um grande número de indivíduos, mostraram que o TBS é associado com fratura vertebral, de colo de fêmur e com outros tipos de fraturas osteoporóticas em mulheres na pós-menopausa. Dados em homens, apesar de escassos, mostram resultados semelhantes. Além disso, o TBS foi associado a fraturas por fragilidade em indivíduos com diversas causas secundárias de osteoporose e, dados preliminares, sugerem que o uso do TBS pode melhorar a previsão de fratura quando incorporado ao sistema de avaliação de risco de fratura (FRAX). Este artigo faz uma revisão de avanços recentes que têm ajudado a estabelecer esse novo mé-todo de imagem. Arq Bras Endocrinol Metab. 2014;58(5):493-503 Descritores

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Identification of Rheumatoid Arthritis Patients With Vertebral Fractures Using Bone Mineral Density and Trabecular Bone Score

Cited by 116 publications

References 21 publications

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice

Trabecular bone score (TBS) as a new complementary approach for osteoporosis evaluation in clinical practice

Quantitative imaging methods in osteoporosis

Trabecular bone score: perspectives of an imaging technology coming of age

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