Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status
Haoshen Shi,
Nazanin Mirzaei,
Yosef Koronyo
et al.
Abstract:This study investigates various pathological tau isoforms in the retina of individuals with early and advanced Alzheimer’s disease (AD), exploring their connection with disease status. Retinal cross-sections from predefined superior-temporal and inferior-temporal subregions and corresponding brains from neuropathologically confirmed AD patients with a clinical diagnosis of either mild cognitive impairment (MCI) or dementia (n = 45) were compared with retinas from age- and sex-matched individuals with normal co… Show more
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