Identification of renal calculi by computerized infrared spectroscopy

Lehmann, Craig; McClure, Gregory L.; Smolens, Iva

doi:10.1016/0009-8981(88)90248-3

Cited by 32 publications

(18 citation statements)

References 10 publications

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“…FT-IR allows the detection of both crystalline and non-crystalline substances detectable. In addition, FT-IR is a sensitive, reliable, accurate, safe and quick, and moderate costs method of accurate stone analysis suitable for use in a clinical laboratory (41)(42)(43).…”

Section: Discussionmentioning

confidence: 99%

Identification of melamine/cyanuric acid‐containing nephrolithiasis by infrared spectroscopy

Chen

Liu

et al. 2010

Clinical Laboratory Analysis

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Melamine-contaminated milk formula caused infant nephrolithiasis in some areas of China. Its combination with cyanuric acid causes crystallization in renal tubules. Following this renal damage and even renal failure that require long-term hemodialysis has been reported. Therefore, correct and timely diagnosis of these complex diseases is critical. Melamine containing stone is a combination of equal molar ratios of common stone compositions that has been reported from previous animal studies. We have previously identified the compositions of urinary tract stones with infrared (IR) spectroscopy. We hypothesized that the absorbance of wavelength of IR can identify melamine/cyanuric acid in the presence of mixing human stone compositions. In this study, we made an artificial stone composition and examine under IR absorbance by mixing equal molar ratios of melamine/cyanuric acid with different types of human urinary stones, and established a reference of IR analysis for the identification of melamine/cyanuric acid-containing human urinary tract stones. Knowledge of the precise stone composition allowed institution of appropriate prophylactic dietary and medical therapy and this may help in the prevention of urinary stone recurrence. The results are promising that melamine and cyanuric acid can be identified clearly in a low percentile (approximately 1%) of stone mixture pellet. Therefore, IR seems to be an ideal tool for the identification of melamine/cyanuric acid-containing stones.

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Section: Discussionmentioning

confidence: 99%

Identification of melamine/cyanuric acid‐containing nephrolithiasis by infrared spectroscopy

Chen

Liu

et al. 2010

Clinical Laboratory Analysis

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“…At present, numerous methods are available for stone analysis, but apart from FT-IR, none of these techniques is able to provide a reliable quantitative analysis. Moreover, with a computerized reference library match of the closest IR spectrum, FT-IR can virtually characterize any stone sample (24).…”

Section: Discussionmentioning

confidence: 99%

Compositional analysis of various layers of upper urinary tract stones by infrared spectroscopy

Zhang

Zheng

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The objective of the present study was to determine the composition of various layers of upper urinary stones and assess the mechanisms of stone nucleation and aggregation. A total of 40 integrated urinary tract stones with a diameter of >0.8 cm were removed from the patients. All of the stones were cut in half perpendicularly to the longitudinal axis. Samples were selected from nuclear, internal and external layers of each stone. Fourier transform infrared spectroscopy (FT-IR) was adopted for qualitative and quantitative analysis of all of the fragments and compositional differences among nuclear, internal and external layers of various types of stone were subsequently investigated. A total of 25 cases of calcium oxalate (CaOx) stones and 10 cases of calcium phosphate (CaP) stones were identified to be mixed stones, while 5 uric acid (UA) calculi were pure stones (purity, >95%). In addition, the contents of CaOx and carbapatite (CA.AP) crystals in various layers of the mixed stones were found to be variable. In CaOx stones, the content of CA.AP in nuclear layers was significantly higher than that of the outer layers (32.0 vs. 6.8%; P<0.05), while the content of CaOx was lower in the inner than in the outer layers (57.6 vs. 86.6%; P<0.05). In CaP stones, the content of CA.AP in the nuclear layers was higher than that in the outer layers (74.0 vs. 47.3%; P<0.05), while the content of CaOx was lower in the inner than in the outer layers (7.0 vs. 40.0%; P<0.05). The UA stones showed no significant differences in their composition among different layers. In conclusion, FT-IR analysis of various layers of human upper urinary tract stones revealed that CaOx and CaP stones showed differences in composition between their core and surface, while all of the UA calculi were pure stones. The composition showed a marked variation among different layers of the stones, indicating that metabolism has an important role in different phases of the evolution of stones. The present study provided novel insight into the pathogenesis of urinary tract stones and may contribute to their prevention and treatment. IntroductionUrolithiasis, a worldwide endemic condition arising from malnutrition, has significantly impacted health-care systems in previous years due to the growing cost of diagnosis and treatment of stone episodes (1-3). Urolithiasis is a common urologic disease with multiple etiologies and risk factors. Studies have suggested an increase in the incidence of urolithiasis in developed nations over recent decades (4,5). The prevalence is 1-5% in Asia, 5-9% in Europe, 13% in North America and 20% in Saudi Arabia, and increasing throughout the world (4). The increase in incidence of urolithiasis was most likely associated with changes in environmental factors, including dietary habits, fluid intake and obesity (6). Historically, urolithiasis has been indicated to be more common among men than women (7). Early epidemiological studies placed the incidence rate of urolithiasis in men at 2.2 to 3.4 times that of women (8). ...

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“…The computerized assessment of infrared spectra of urinary stones with existing programmes such äs SEARCH (Lehmann, C. A. et al (1988) Clin. Chim.…”

Section: Discussionmentioning

confidence: 99%

“…From the Information contained in the literature (6) and from our own experience with other programs we are confident that STONES will soon provide a program acceptable for all routine urinary stone analysis purposes.…”

Section: Overall Assessment Of Stonesmentioning

confidence: 99%

“…However, over 65% of all concrements are of jnixed composition,>vith the result that the existing programs such äs SEARCH (6), TWIN or CIRCOM (7), with their general rules for automated spectrum assessment, have proved to be very unreliable when used for routine urinary stone analysis. Hence a new program -STONES -has been written which has been specially tailored to accommodate urinary stone sübstances of every known composition.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of Urinary Stones by Computerized Infrared Spectroscopy

Hesse

Gergeleit²,

Schuller³

et al. 1989

Clinical Chemistry and Laboratory Medicine

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Summary:The computerized assessment of infrared spectra of urinary stones with existing programmes such äs SEARCH (Lehmann, C. A. et al. (1988) Clin. Chim. Acta 773, 107-116), TWIN or CIRCOM (Hesse, A. et al. (1988) Fresenius Z. Anal. Chem. 330, 372-373) has proved to be unreliable when used for routine urinary stone analysis. A more refined method has to be used in place of simple comparison algorithms. STONES is a new Programme for computerized analysis of urinary stones developed with the intention of simulating the former non-computerized analysis procedure. STONES is a rule-based System, which interprets the infrared spectra qualitatively by its rules. A quantitative result is obtained by means of library search. Combining these two methods 93% of the tests were correct with regard to clinical relevance.

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Identification of renal calculi by computerized infrared spectroscopy

Cited by 32 publications

References 10 publications

Identification of melamine/cyanuric acid‐containing nephrolithiasis by infrared spectroscopy

Identification of melamine/cyanuric acid‐containing nephrolithiasis by infrared spectroscopy

Compositional analysis of various layers of upper urinary tract stones by infrared spectroscopy

Analysis of Urinary Stones by Computerized Infrared Spectroscopy

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