Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers
Sofie Joris,
Philippe Giron,
Catharina Olsen
et al.
Abstract:Background
Among the 10% of pancreatic cancers that occur in a familial context, around a third carry a pathogenic variant in a cancer predisposition gene. Genetic studies of pancreatic cancer predisposition are limited by high mortality rates amongst index patients and other affected family members. The genetic risk for pancreatic cancer is often shared with breast cancer susceptibility genes, most notably BRCA2, PALB2, ATM and BRCA1. Therefore, we hypothesized that additional shared genetic e… Show more
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