Identification of putative new tomato allergens and differential interaction with IgEs of tomato allergic subjects

Abstract

The hypothesis that high interindividual differences in allergic reactions are based on the interactions between the IgEs of allergic subjects with particular allergens has to be rejected. However, five proteins with putative clinical relevance as tomato allergens could be newly identified.

Two nonspecific lipid transfer proteins (nsLTPs) from tomato seeds are associated to severe symptoms of tomato‐allergic patients

“…Studies on tomato allergy have been focussed in patients sensitized to pulp and peel of the fruit . Tomato is one of the most consumed and cultured food worldwide an increase that has grown together with the allergic incidence . The prevalence of sensitization to this food ranges from 1.5 to 25.0% depending on the population studied.…”

A Recombinant Sal k 1 Isoform as an Alternative to the Polymorphic Allergen from <b><i>Salsola kali</i></b> Pollen for Allergy Diagnosis

“…The role of Amaranthaceae pollens as an important source of allergy has special relevance in countries with a desert climate, high temperatures and dry soil [22], and also extensively in areas of the south of Europe which have suffered from an increased desertification process in recent years [4,5]. Although S. kali is considered the main allergenic pollen from Salsola sp., and their pollen allergens have been studied extensively in the last years [6], other Salsola sp.…”

“…Second, the existence of allergenic PMEs in pollen, e.g. Ole e 11 in olive pollen, with a range of prevalence of 55.9-75.6% in 3 different allergic populations [20], and plant-derived foods like tomato [21,22] or kiwi (Act d 7), with a 32% prevalence [23], could be indicative of a protein involved in cross-reactivity processes. And third, it was recently published that there is a higher prevalence of Sal k 1 in patients sensitized to plant-derived food and pollen than in patients sensitized only to pollen [19], suggesting a potential implication of this allergen in pollen to plant-derived food cross-reactivity.…”

“…In addition to Sal k 1, PMEs from olive (Olea europaea) pollen (Ole e 11), tomato (Lycopersicon esculentum) and kiwi fruit (Actinidia deliciosa) have also been reported as allergens [20,21,22,23]. Sal k 1 shares an amino acid sequence identity of 57, 17 and 23% with olive pollen, tomato and kiwi PMEs, respectively.…”

Definition und Design hypoallergener Nahrungsmittel

“…Etwa 32 % der Nahrungsmittelallergiker [41] und 22 % der Tomatenallergiker sind auf Tomatenpro lin Sola l 1 [42], 17 % auf Sola l 2 (Invertase) [43] und 35 % der spanischen Patienten mit Fruchtallergie auf Sola l 3 (nsLTP) sensibilisiert [4], während eine Sensibilisierung auf Sola l 3 (nsLTP), das resistent gegen Hitze-und Pepsineinwirkung ist und zu schweren systemischen allergischen Symptomen führen kann, bei tomatenallergischen Patienten in Deutschland eine Rarität darstellt [44]. Darüber hinaus wurden zahlreiche weitere putative Tomatenallergene beschrieben [46,47,48,49,50]. Bei einer Aminosäurenidentität von über 40 % und ähnlicher Proteinstruktur besteht eine ausgeprägte Kreuzreaktivität zwischen den beiden PR-10-Proteinen Sola l 4 und Bet v 1 [45].…”