2022
DOI: 10.1101/2022.10.12.511664
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Identification of putative GATA3 regulatory elements and comparison of GATA3 distribution in cochleae of mice, rats, macaques, and humans

Abstract: The transcription factor GATA3 plays a critical role in the development of neurons and sensory epithelia of the inner ear. In mouse cochleae, GATA3 is downregulated in certain supporting cells (SCs) and in type I spiral ganglion neurons (SGNs) after development. This reduction of GATA3 in SCs severely limits Atoh1-induced hair cell (HC) regeneration and suggests that a similar downregulation in human cochleae may be limiting for regenerative therapies. However, it is unknown whether GATA3 is similarly or diffe… Show more

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