Identification of proteomic signatures associated with lung cancer and COPD

Pastor, María Dolores; Nogal, Ana; Molina-Pinelo, Sonia; Meléndez, Ricardo; Salinas, Ana; Peña, Miriam Gonzalez de la; Martín-Juan, José; Corral, J.; García‐Carbonero, Rocío; Carnero, Amancio; Paz‐Ares, Luis

doi:10.1016/j.jprot.2013.04.037

Cited by 123 publications

(90 citation statements)

References 61 publications

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“…Using a proteomic-based approach, we identified HLA class I-bound peptides from epithelial, mesenchymal, and IFNγ-treated mesenchymal cells and demonstrated that identified HLA class I-bound peptides are functional, resulting in lung cancer cell killing. Identified functional peptides include those derived from proteins such as PKM2 that have previously described roles in tumor proliferation and survival, as well as proteins such as SERPBINB1, which is part of a previously described lung cancer proteomic signature (40,41).…”

Section: Discussionmentioning

confidence: 99%

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

Tripathi

Peters

Taguchi

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

181

175

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The immunoproteasome plays a key role in generation of HLA peptides for T cell-mediated immunity. Integrative genomic and proteomic analysis of non-small cell lung carcinoma (NSCLC) cell lines revealed significantly reduced expression of immunoproteasome components and their regulators associated with epithelial to mesenchymal transition. Low expression of immunoproteasome subunits in early stage NSCLC patients was associated with recurrence and metastasis. Depleted repertoire of HLA class I-bound peptides in mesenchymal cells deficient in immunoproteasome components was restored with either IFNγ or 5-aza-2′-deoxycytidine (5-aza-dC) treatment. Our findings point to a mechanism of immune evasion of cells with a mesenchymal phenotype and suggest a strategy to overcome immune evasion through induction of the immunoproteasome to increase the cellular repertoire of HLA class I-bound peptides.

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Section: Discussionmentioning

confidence: 99%

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

Tripathi

Peters

Taguchi

et al. 2016

Proc. Natl. Acad. Sci. U.S.A.

181

175

View full text Add to dashboard Cite

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“…Similar to the observations of the present study, CAPS overexpressionhas been found in a range of cancer types, including ovarian cancer (20), ependymoma (14), endometrial cancer (15), lung cancer (16) and colorectal cancer (17). In a study concerning lung cancer and chronic obstructive pulmonary disease (COPD), upregulated CAPS expression was detected in lung cancer and lung cancer with COPD groups when compared with the control group, indicating that CAPS may serve as a biomarker fora lung cancer diagnosis (16). Esophageal cancer is one of the most aggressive cancer types worldwide owing to a lack of early typical symptoms and effective non-invasive diagnostic methods (21).…”

Section: Discussionmentioning

confidence: 99%

Overexpression of calcyphosine is associated with poor prognosis in esophageal squamous cell carcinoma

Zhu

Yang

et al. 2017

Oncol Lett

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Abstract. Calcyphosine (CAPS), a calcium-binding protein, has been identified as a potential diagnostic and prognostic biomarker in several human carcinomas. However, little is known about CAPS in esophageal squamous cell carcinoma (ESCC). The present study aimed to investigate the expression levels of CAPS in ESCC tissues and evaluate its clinicopathological significance. Reverse transcription-quantitative polymerase chain reaction and immunohistochemical staining were conducted to detect the expression of CAPS in ESCC tissues and adjacent non-cancerous tissues. ESCC samples exhibited higher levels of CAPS mRNA than paired non-cancerous samples (P=0.0015), and the mRNA level of CAPS was positively associated with histological grade (P=0.0013) and tumor invasion depth (P=0.0206). In addition, Kaplan-Meier survival analysis revealed that patients with high CAPS expression experienced significantly shorter 5-year overall survival times than those with low CAPS expression (P=0.0112). Multivariate analysis demonstrated that CAPS protein expression was an independent prognostic biomarker for patients with ESCC. In conclusion, the findings of the present study demonstrated that CAPS may represent a novel diagnostic indicator and an independent prognostic biomarker in ESCC.

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“…Smokers develop lung cancer a 10-fold higher than non-smokers. Lung cancer (LC) and chronic obstructive pulmonary disease (COPD) commonly coexist in smokers, and the presence of COPD increases the risk of developing LC [148].…”

Section: Lung Cancermentioning

confidence: 99%

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

2014

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Free radicals and other oxidants have gained importance in the field of biology due to their central role in various physiological conditions as well as their implication in a diverse range of diseases. The free radicals, both the reactive oxygen species (ROS) and reactive nitrogen species (RNS), are derived from both endogenous sources (mitochondria, peroxisomes, endoplasmic reticulum, phagocytic cells etc.) and exogenous sources (pollution, alcohol, tobacco smoke, heavy metals, transition metals,

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Identification of proteomic signatures associated with lung cancer and COPD

Cited by 123 publications

References 61 publications

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

Immunoproteasome deficiency is a feature of non-small cell lung cancer with a mesenchymal phenotype and is associated with a poor outcome

Overexpression of calcyphosine is associated with poor prognosis in esophageal squamous cell carcinoma

Free Radicals: Properties, Sources, Targets, and Their Implication in Various Diseases

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