Identification of potentially actionable genetic variants in epithelial ovarian cancer: a retrospective cohort study
Charlotte Fieuws,
Joni Van der Meulen,
Kristiaan Proesmans
et al.
Abstract:Ovarian cancer is the most lethal gynecologic malignancy, mainly due to late-stage diagnosis, frequent recurrences, and eventually therapy resistance. To identify potentially actionable genetic variants, sequencing data of 351 Belgian ovarian cancer patients were retrospectively captured from electronic health records. The cohort included 286 (81%) patients with high-grade serous ovarian cancer, 17 (5%) with low-grade serous ovarian cancer, and 48 (14%) with other histotypes. Firstly, an overview of the preval… Show more
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