Identification of potential therapeutic role of thymus capitatus essential oil using cellular imaging

Yavuz, Dudu Özkum; Mavis, Merdiye; Ateş, Gülperi; Hanoğlu, Azmi; Hanoğlu, Duygu Yiğit; Başer, Kemal Hüsnü Can; Serakıncı, Nedime

doi:10.1016/j.procs.2017.11.332

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…There are many reported studies that support the anticancer potential of Thyme oil and its components toward various types of cancer cells including lung, oral, ovarian, breast, colon, prostate, and leukemia. The mechanisms of action may involve inducing apoptosis (programmed cell death), inhibiting cell proliferation, modulating cell signaling pathways, and enhancing the immune system. − The potential to inhibit metastasis, a critical aspect of cancer, , was also explored. Thyme oil showed antiproliferative activity, suggesting its potential in preventing metastasis.…”

Section: Resultsmentioning

confidence: 99%

Network Pharmacology Combined with Molecular Docking, Molecular Dynamics, and In Vitro Experimental Validation Reveals the Therapeutic Potential of Thymus vulgaris L. Essential Oil (Thyme Oil) against Human Breast Cancer

Alotaibi,

Alshammari

et al. 2023

ACS Omega

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Section: Resultsmentioning

confidence: 99%

Network Pharmacology Combined with Molecular Docking, Molecular Dynamics, and In Vitro Experimental Validation Reveals the Therapeutic Potential of Thymus vulgaris L. Essential Oil (Thyme Oil) against Human Breast Cancer

Alotaibi,

Alshammari

et al. 2023

ACS Omega

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“…Few studies were performed on Tc to explore its cytotoxic activity (Kaileh et al, 2007;Dzamic et al, 2015;Yavuz et al, 2017). According to Dzamic et al, , , , a study was carried out on Tc using tetrazolium (MTT) colorimetric assay.…”

Section: Introduction Introduction Introduction Introductionmentioning

confidence: 99%

Cytotoxic activity of Thymus capitatus collected from Hail region in Saudi Arabia with mechanistic study via induction of caspase-dependent apoptosis and S-phase arrest

Younes

HUWAIMEL

ALRASHIDI

et al. 2022

Not Bot Horti Agrobo

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Thymus capitatus is a plant grows in Mediterranean area and some Arab countries such as Saudi Arabia. It possesses numerous medicinal values. Its common name is Zaatar and it belongs to family Lamiaceae Thymus capitatus leaves and stem were collected from Hail region, Saudi Arabia. Then both leaves and stem were extracted with ethanol. This study was performed to evaluate cytotoxic activity of Thymus capitatus leaves and stem ethanolic extract in details. Doxorubicin was used as a standard and the relevant half maximal inhibitory concentration (IC50) values were computed for each cell line by 3-(4,5- diemthylthiazole-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. In addition, further mechanistic study was carried out by using Apoptosis assay to explore cytotoxic activity of plant extract. Both leaves and stems extracts were screened against HepG2, A-549, HCT-116 and MCF-7 cancer cell lines. It was found that leaves’ extract shows high and moderate cytotoxic activity against both A-549 and HepG2 cancer cell lines, respectively (with IC50 = 13.6 and 21.5 μg/ml, respectively), while stem’s extract exerted moderate cytotoxic activity against A-549 cancer cell lines (with IC50 = 21.38 μg/ml). Further mechanistic study was carried out on A-549 cells by using apoptosis assay. It showed that leaves’ extract resulted in arrest of S-phase and caused apoptosis through activation of caspase-3, p53 and Bax, in addition to down regulation of Bcl-2.

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Biotoxicity of Colocasia esculenta [Linn.]: Involvement of Colocasia esculenta leaf in preservation of staple from Sitophilus zeamais [Motschulsky] attack

Oriyomi

Fagbohun

Oyedeji

et al. 2022

Industrial Crops and Products

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Identification of potential therapeutic role of thymus capitatus essential oil using cellular imaging

Cited by 5 publications

References 11 publications

Network Pharmacology Combined with Molecular Docking, Molecular Dynamics, and In Vitro Experimental Validation Reveals the Therapeutic Potential of Thymus vulgaris L. Essential Oil (Thyme Oil) against Human Breast Cancer

Network Pharmacology Combined with Molecular Docking, Molecular Dynamics, and In Vitro Experimental Validation Reveals the Therapeutic Potential of Thymus vulgaris L. Essential Oil (Thyme Oil) against Human Breast Cancer

Cytotoxic activity of Thymus capitatus collected from Hail region in Saudi Arabia with mechanistic study via induction of caspase-dependent apoptosis and S-phase arrest

Biotoxicity of Colocasia esculenta [Linn.]: Involvement of Colocasia esculenta leaf in preservation of staple from Sitophilus zeamais [Motschulsky] attack

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