Identification of potential migrants from a vinylic organosol varnish by gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry

Cottier, S.; Riquet, Anne‐Marie; Feigenbaum, Alexandre; Pollet, Brigitte; Lapierre, C.; Mortreuil, P.

doi:10.1016/s0021-9673(97)00145-3

Cited by 22 publications

(14 citation statements)

References 6 publications

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“…The 3 isolated substances I, II and III were analysed by NMR and MS and found to be p,p′‐DGEBF, o,p′‐DGEBF and o,o′‐DGEBF, respectively. I: 1 H NMR, 13 C NMR and EI MS data from the isolated substance corresponded to published data for p,p′‐DGEBF (15, 17, 18); MP 69.7–73.0 °C. II: 1 H NMR and EI MS data from the isolated substance corresponded to published data for o,p′‐DGEBF (15, 18); HRMS (FAB+) calculated for C 19 H 20 O 4 [M] + : 312.1361, found: 312.1366; MP 63.9–65.7 °C.…”

Section: Methodssupporting

confidence: 56%

“…I: 1 H NMR, 13 C NMR and EI MS data from the isolated substance corresponded to published data for p,p′‐DGEBF (15, 17, 18); MP 69.7–73.0 °C. II: 1 H NMR and EI MS data from the isolated substance corresponded to published data for o,p′‐DGEBF (15, 18); HRMS (FAB+) calculated for C 19 H 20 O 4 [M] + : 312.1361, found: 312.1366; MP 63.9–65.7 °C. III: 1 H NMR and EI MS data from the isolated substance corresponded to published data for o,o′‐DGEBF (15, 18); HRMS (FAB+) calculated for C 19 H 20 O 4 [M] + : 312.1361, found: 312.1367; MP 87.8–88.5 °C.…”

Section: Methodssupporting

confidence: 56%

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Chemical analysis of monomers in epoxy resins based on bisphenols F and A

et al. 2004

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Diglycidyl ether of bisphenol A (DGEBA) is the monomer and most important contact allergen in epoxy resin(s) based on bisphenol A (DGEBA-R). Both thin-layer chromatography (TLC) and high-pressure liquid chromatography (HPLC) methods are available for the analysis of products containing DGEBA-R. With respect to detection and quantification, epoxy resins of the bisphenol F-type, i.e. epoxy resins containing the isomers of diglycidyl ethers of bisphenol F (DGEBF), are not as well investigated as DGEBA-R. The isomers of DGEBF are p,p'-DGEBF, o,p'-DGEBF and o,o'-DGEBF. Both p,p'-DGEBF and o,p'-DGEBF have been shown to be contact allergens in humans, and all 3 isomers are sensitizers in the guinea pig maximization test. We aimed (i). to develop HPLC methods for separation and purification of the individual DGEBF isomers, (ii). to detect and quantify the DGEBF isomers in epoxy resins of the bisphenol F-type and (iii). to evaluate and develop the TLC as a method for the detection of the DGEBF monomers. We found the total content of the DGEBF isomers in the investigated epoxy resins of the bisphenol F-type to vary from 17.0 to 81.7% w/w. Some of them also contained 0.1-2.4% w/w DGEBA. The HPLC method showed a sensitivity that was 2000-20 000x higher than that obtained with the TLC method for the DGEBF monomers. We concluded that the range of the DGEBF isomer content in epoxy resins of the bisphenol F-type is approximately the same as the monomer content in liquid compared to solid DGEBA-R. The relevance of contact allergy to DGEBA-R can remain unrecognized if the suspected product is an epoxy resin of the bisphenol F-type, which is analysed with the TLC method.

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Section: Methodssupporting

confidence: 56%

Section: Methodssupporting

confidence: 56%

Chemical analysis of monomers in epoxy resins based on bisphenols F and A

et al. 2004

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“…Most of the times this technique was used just to confirm positively the presence of these compounds after HPLC quantification with fluorescence detection [11,14,21,26]. Some works are focused on the identification of these substances and other oligomers of higher molecular mass using HPLC with detection by atmospheric pressure chemical ionisation (APCI) [27][28][29][30], thermospray mass spectrometry (TSP) [31] and electrospray ionisation (ESI) [29,32]. The characterisation of BADGE hydrolysis products has also been described by other authors [33].…”

Section: Introductionmentioning

confidence: 99%

Determination of bisphenol A diglycidyl ether and its hydrolysis and chlorohydroxy derivatives by liquid chromatography–mass spectrometry

Garcı́a

Losada

2004

Journal of Chromatography A

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“…aromatic rings) and oligomers or derivatives, using HPLC with MS detection using atmospheric pressure chemical ionisation mode (APCI), 3,[17][18][19] thermospray ionisation (TSP), 7 or electrospray ionisation (ESI). 19 The present work describes an RP-HPLC/APCI-MS technique that allows both the quantification and positive identification of NOGE and BFDGE derivatives.…”

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confidence: 99%

“…19 The present work describes an RP-HPLC/APCI-MS technique that allows both the quantification and positive identification of NOGE and BFDGE derivatives. To the best of our knowledge this is the first report of a method to quantify BFDGE and its related compounds using this technique.…”

mentioning

confidence: 99%