Identification of potential angiotensin-I-converting enzyme inhibitory components in celery seed using UHPLC-MS and molecular docking

Ma, Zijia; Zheng, Meiyu; Liu, Zhe; Lu, Hanyu; Liu, Yinying; Fang, Zhongxiang; Lu, Shengmin

doi:10.1016/j.procbio.2023.02.025

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…In addition, Branković et al [ 36 ] further demonstrated that both aqueous and ethanol extracts of celery can lower blood pressure and reduce the contractility of isolated atria, potentially mediated by muscarinic receptor stimulation [ 36 ]. A recent molecular study conducted by Ma et al [ 37 ] revealed that many components in celery seeds play main roles in the ACE inhibitory activity including flavonoids, terpenoids, and carbohydrates. It is worth noting that ultrafiltration technique in this study increases ACE inhibitory activity of celery seed aqueous extract [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

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Antihypertensive Property of Celery: A Narrative Review on Current Knowledge

Alobaidi,

Saleh

2024

International Journal of Food Science

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Background. The incidence of hypertension is increasing significantly on a global scale, and it is considered the leading cause of heart disease and death. Despite the availability of hypotensive drugs, they have many side effects that decrease adherence to treatments and lead to uncontrolled blood pressure. Studies have revealed that celery contains bioactive compounds that oppose hypotensive effect. Methods. A thorough literature review was conducted using Scopus, PubMed, and Google Scholar databases. To identify relevant studies on the topic, our search strategy employed keywords such as “celery,” “Apium gravenols L,” “hypertension,” “high blood pressure,” “apigenin,” “antihypertensive,” and “hypotensive.” The search was limited to articles published between January 2013 and December 2023. The inclusion criteria were original research articles that involved both animal and human subjects, published in English, and reported results applicable to the subject of this review. Review articles or articles in the form of theses or books were excluded. Results. The available evidence revealed that celery enhances blood pressure parameters. Clinical trials clarified that celery possesses its effect through many bioactive compounds, specifically 3-n-butylphthalide and apigenin. Based on animal and human studies, celery seems to elicit blood pressure regulation mainly by the vasodilatory, diuretic, and calcium channel-blocking properties. Furthermore, celery seed extract seems to exert a bradycardia effect. Conclusion. The current literature review showed a considerable number of studies on the hypertensive models, which confirmed that celery and its extracts are effective hypotensive agents. Some limitations in comparing published data should be considered, including differences in doses, extracts, species of celery, and administration form.

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Section: Discussionmentioning

confidence: 99%

“…A recent molecular study conducted by Ma et al [ 37 ] revealed that many components in celery seeds play main roles in the ACE inhibitory activity including flavonoids, terpenoids, and carbohydrates. It is worth noting that ultrafiltration technique in this study increases ACE inhibitory activity of celery seed aqueous extract [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Property of Celery: A Narrative Review on Current Knowledge

Alobaidi,

Saleh

2024

International Journal of Food Science

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“…Numerous medical studies have shown that celery seeds have good medicinal value. For example, the seed extract can be used to treat hypertension, alleviate gout [4], prevent cardiovascular disease [5], prevent Alzheimer's disease [6], and inhibit cancer cell growth [7]. Moreover, celery seed powder is an effective nutritional supplement.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Impact of Origins on the Quality Characteristics of Celery Seeds Based on Metabolite Analysis through HS-GC-IMS, HS-SPME-GC-MS and UPLC-ESI-MS/MS

Yan,

He,

Huang

et al. 2024

Foods

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Celery seeds contain various bioactive compounds and are commonly used as a spice and nutritional supplement in people’s daily lives. The quality of celery seeds sold on the market varies, and their regions of production are unclear. This study evaluated the metabolites of Chinese celery seeds from three production regions using HS-SPME-GC-MS, HS-GC-IMS, and UPLC-ESI-MS/MS. The results indicate that GC-IMS analysis obtained a metabolic profile different from that detected using GC-MS. Terpenoids, polyphenols, coumarins, and phthalides are the main bioactive compounds in celery seeds. The production region significantly affects the metabolic characteristics of celery seeds. Based on GC-MS data, GC-IMS data, and LC-MS data, the variation analysis screened 6, 12, and 8 metabolites as potential characteristic metabolites in celery seeds related to the production region, respectively. According to the aromatic characteristics of the characteristic metabolites, seeds from the HCQ region and HZC region have a strong herbal, woody, celery, and turpentine aroma. The concentration of secondary metabolites was highest in the seeds from the HCQ region followed by the HZC region, and it was the lowest in the JJC region. Altogether, this study investigates how geographical origins influence the metabolomic profile of celery seeds. The results can be used to guide the planting and harvesting of celery seeds in suitable regions.

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Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman

Siripongvutikorn,

Pumethakul,

Yupanqui

et al. 2024

Foods

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Food is one of the factors with the highest impact on human health. Today, attention is paid not only to food properties such as energy provision and palatability but also to functional aspects including phytochemical, antioxidant properties, etc. Massaman and spicy basil leaf curries are famous Thai food dishes with a good harmony of flavor and taste, derived from multiple herbs and spices, including galangal rhizomes, chili pods, garlic bulbs, peppers, shallots, and coriander seeds, that provide an array of health benefits. The characterization of phytochemicals detected by LC-ESI-QTOF-MS/MS identified 99 components (Masaman) and 62 components (spicy basil leaf curry) such as quininic acid, hydroxycinnamic acid, luteolin, kaempferol, catechin, eugenol, betulinic acid, and gingerol. The cynaroside and luteolin-7-O-glucoside found in spicy basil leaf curry play a key role in antioxidant activities and were found at a significantly higher concentration than in Massaman curry. Phenolic and flavonoid compounds generally exhibit a bitter and astringent taste, but all the panelists scored both curries higher than 7 out of 9, confirming their acceptable flavor. Results suggest that the Massaman and spicy basil leaves contain various phytochemicals at different levels and may be further used as functional ingredients and nutraceutical products.

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Identification of potential angiotensin-I-converting enzyme inhibitory components in celery seed using UHPLC-MS and molecular docking

Cited by 3 publications

References 32 publications

Antihypertensive Property of Celery: A Narrative Review on Current Knowledge

Antihypertensive Property of Celery: A Narrative Review on Current Knowledge

Investigating the Impact of Origins on the Quality Characteristics of Celery Seeds Based on Metabolite Analysis through HS-GC-IMS, HS-SPME-GC-MS and UPLC-ESI-MS/MS

Phytochemical Profiling and Antioxidant Activities of the Most Favored Ready-to-Use Thai Curries, Pad-Ka-Proa (Spicy Basil Leaves) and Massaman

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