Identification of Phytocomponents and Acute Toxicity Evaluation of Corchorus olitorius Leaf Extract

Orieke, Daniel; Ohaeri, O. C.; Ijeh, Ifeoma I.; Ijioma, Solomon Nnah

doi:10.9734/ejmp/2018/38739

Cited by 15 publications

(19 citation statements)

References 4 publications

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“…This might be that ethanolinduced oxidative stress generated elevated ROS in the liver which CAT tend to combat, thereby increasing its activity. C. olitorius was able to reduce the ROS generation with subsequent decrease in CAT activity due to its high phytochemical content as reported by Orieke et al [52]. Increased CAT activity in this study following acute ethanol exposure suggests elevated ethanol oxidation and formation of oxidizing product-acetaldehyde.…”

Section: Discussionsupporting

confidence: 82%

“…This might be that ethanol-induced oxidative stress generated elevated ROS in the liver which SOD tend to combat thereby increasing its activity. C. olitorius was able to reduce the ROS generation with subsequent decrease in SOD activity due to its high phytochemical content as reported by Orieke et al [52]. The increased activity of SOD observed in ethanol induced animals contradicts the study of Halliwell and Gutterberidge [55] who reported that SOD activity was considerably reduced during ethanol intoxication.…”

Section: Discussionmentioning

confidence: 76%

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Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Airaodion

Ogbuagu

Ogbonnaya

et al. 2019

AJBGMB

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Aim: This study is aimed at investigating the ameliorative efficacy of methanolic extract of Corchorus olitorius leaves against acute ethanol-induced oxidative stress in Wistar rats. Methods: Fresh plants of C. olitorius were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol as the solvent. The methanol was evaporated in a rotary evaporator at 35°C with a yield of 2.17 g which represents a percentage yield of 8.68%. Twenty adult male Wistar rats with body weight between 120 and 150 g were used for this study. They were randomly divided into four groups of five rats each. Animals in groups 1 and 2 were administered saline solution while those in groups 3 and 4 were administered C. olitorius extract for twenty-one days. The animals were administered the extract and saline solution at a dose of 4 mL per 100 g body weight 12 hourly via oral route of administration. At the end of the treatment, they were fasted overnight and animals in groups 2 and 4 were exposed to a single dose of 70% ethanol at 12 ml/kg body weight to induce oxidative stress. After 12 hours of ethanol administration, the animals were anaesthetized using diethyl ether and were sacrificed. Liver was excised, weighed and homogenized in 50 mmol/L Tris–HCl buffer (pH 7.4) and then centrifuged at 5000 × g for 15 minutes for biochemical analysis. Supernatants were immediately kept frozen for further analysis. Results: Ethanol-induced oxidative stress significantly increased the activities of AST, ALT, LDH, LPO, CAT, SOD and GPX but decrease GSH. These effects were regulated by C. olitorius administration. Conclusion: C. olitorius was able to remedy the effect of ethanol by regulating the oxidative stress biomarkers, thus possesses ameliorative efficacy against ethanol-induced oxidative stress and can protect the body against free radicals arising from oxidative stress.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 76%

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Airaodion

Ogbuagu

Ogbonnaya

et al. 2019

AJBGMB

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“…Chemical investigation of C. olitorius leaves has shown that they contain flavonoids, alkaloids, glycoside, and phenolic compounds [13]. These chemical substances may then be responsible for the hypoglycemic effect of C. olitorius leaves observed in this study.…”

Section: Discussionmentioning

confidence: 58%

“…Nutritional substances; including calcium, potassium, phosphate, iron, ascorbic acid, carotene and large amount of mucilaginous polysaccharides have all been identified in the plant [12]. The phytochemical composition and its toxicity have also been investigated [13]. Medicinally, C. olitorius are used as a demulcent, diuretic, purgative, bitter tonic, laxative, refrigerant, carminative and lactagogue [14].…”

Section: Introductionmentioning

confidence: 99%

“…Medicinally, C. olitorius are used as a demulcent, diuretic, purgative, bitter tonic, laxative, refrigerant, carminative and lactagogue [14]. The leaves extract has given positive results in the management of chronic cystitis and dysuria [13]. Its reported high antibacterial activity gives credence to its use traditionally for the treatment of dysentery, fever and gonorrhea [12,14].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Methanolic Extract of Corchorus olitorius Leaves on Hypoglycemic and Hypolipidaemic Activities in Albino Rats

Airaodion

Akinmolayan²,

Ogbuagu

et al. 2019

APRJ

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Aim: This study sought to investigate the hypoglycemic and hypolipidaemic effect of methanolic extract of Corchorus olitorius leaves in Albino rats. Methods: Fresh plants of C. olitorius were harvested from the Institute of Agricultural Research and Training, Ibadan. The leaves were dried and extracted using soxhlet apparatus and methanol as the solvent. The methanol was evaporated in a rotary evaporator at 35°C with a yield of 2.17 g which represents a percentage yield of 8.68%. Ten adult male albino rats with body weight between 100 and 120 g were used for this study. They were randomly divided into two groups of five rats each. Animals in group 1 were administered saline solution while those in group 2 were administered C. olitorius extract. The animals were exposed to the extract and saline solution at a dose of 3 mL per 100 g body weight 12 hourly via oral route of administration. After fourteen days of administration, the animals were fasted overnight and anaesthetized using diethyl ether. Blood samples were collected by cardiac puncture. Fasting blood sugar and lipid profile were determined using standard methods. Results: C. olitorius leaves was observed to significantly lower fasting blood sugar, total cholesterol, LDL-cholesterol and triglyceride but increased HDL-cholesterol and HDL/LDL-cholesterol ratio significantly when compared to those of the control group at p<0.05. Conclusion: The result of this study implies that C. olitorius leaves are of significant health importance as far as hyperglucosemia and hyperlipidaemia is concerned. It could also be exceedingly helpful in the control of obesity and hypertension. This pharmacological study is a useful tool for further drug development from the natural plant products.

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Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models

Orieke

Ohaeri

Ijeh

et al. 2020

Journal of Ethnopharmacology

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Identification of Phytocomponents and Acute Toxicity Evaluation of Corchorus olitorius Leaf Extract

Cited by 15 publications

References 4 publications

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Ameliorative Efficacy of Phytochemical Content of Corchorus olitorius Leaves against Acute Ethanol-induced Oxidative Stress in Wistar Rats

Effect of Methanolic Extract of Corchorus olitorius Leaves on Hypoglycemic and Hypolipidaemic Activities in Albino Rats

Gastrointestinal and uterine smooth muscles relaxant and anti-inflammatory effects of corchorus olitorius leaf extract in laboratory animal models

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