In this work, Artificial Neural Network (ANN) modelling has been employed to investigate the effects of various factors on the biodynamic responses to vibration represented by the transmissibility and its phase. These factors include, height, weight, Body Mass Index (BMI), age, frequency and posture. Nine subjects stood on a vibrating plate and were exposed to vertical vibration at nine frequencies in the range 17-46 Hz while adopting four different standing postures; Bent Knee posture (BK), Locked Knee posture (LK), right foot to the Front and left foot to the Back posture (FB) and One Leg posture (OL). The accelerations of the vibrating plate and the head of the subjects were measured during the exposure to vibration in order to calculate the transmissibility between the vibrating plate and the head. Genetic Algorithm (GA) was used to choose ANN’s number of hidden layers and number of neurons in each layer to obtain the best performance for predicting the transmissibility. The GA compared the root mean square errors (RMSE) between the ANN outputs and the experimental outputs, and then choose the best results that could be achieved. The number of hidden layers and number of neurons tested in GA vary from one hidden layer to four hidden layers, and from one neuron per layer to one hundred neurons per layer. Several runs have been conducted to train and validate the ANN model. The results show that double hidden layer with 13 neurons in the first layer and 12 neurons in the second layer give the best candidate. The proposed model can be integrated with whole-body vibration machines in order to choose the suitable exposure based on the user’s characteristics.