Identification of Phthalate Esters in the Serum of Young Puerto Rican Girls with Premature Breast Development

Colón, Ivelisse; Caro, Doris; Bourdony, Carlos J.; Rosario, Osvaldo

doi:10.2307/3434999

Cited by 100 publications

(122 citation statements)

References 9 publications

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“…Nowadays, due to its massive use and persistent character, PAEs are considered as ubiquitous environmental pollutants. A number of researches proved that PAEs exerted a pernicious impact on human health; furthermore, some PAEs can cause endocrine system disorders [4,5], produce carcinogenic effects and afflict the development of reproductive system [6].…”

Section: Introductionmentioning

confidence: 99%

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Cai

Shi

et al. 2008

Talanta

155

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Ionic liquid mixed hemimicelles-based solid-phase extraction for the preconcentration of five phthalates in environmental water sample was investigated in this paper. A comparative study on the use of room temperature ionic liquids (RTILs) 1-hexyl-3-methylimidazolium bromide ([C 6 mim]Br) and 1-dodecyl-3-methylimidazolium bromide ([C 12 mim]Br)-coated silica as sorbents was presented. Owing to having bigger adsorption amounts for analytes [C 12 mim], Br-coated silica was selected as SPE material and the five analytes di-ethyl-phthalate (DEP), di-n-propyl-phthalate (DnPP), di-n-butyl-phthalate (DnBP), di-cyclohexyl-phthalate (DcHP) and di-(2-ethylhexyl)-phthalate (DEHP) can be quantitatively extracted under optimal conditions. The analytes retained on the cartridge were desorbed completely with 3 mL methanol (pH 2). Predominant factors influencing the extraction efficiency, such as RTILs concentration, pH value, ionic strength and breakthrough volume were discussed. The proposed method had been applied to determining the five phthalates in four environmental water samples and concentration factor of 600 was achieved easily. Detection limits obtained ranged between 0.12 and 0.17 g/L. The accuracy of this method was evaluated by recovery measurement on spiked samples, and good recovery results (85-107%) with relative standard deviation (R.S.D.) of below 6% were achieved.

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Section: Introductionmentioning

confidence: 99%

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Cai

Shi

et al. 2008

Talanta

155

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“…In Puerto Rico, 41 girls with early thelarche had much higher levels of 4 phthalates than 35 control girls (Colón et al, 2000); however, a commentary 3 years later pointed out that the results were consistent with contamination of the serum samples in the lab (McKee and Toxicology Research Task Group, 2004), where phthalate containing equipment is common. No studies confirming or refuting this study have appeared, despite the very strong apparent effect.…”

Section: Adolescent Growth and Sexual Maturationmentioning

confidence: 95%

Some evidence of effects of environmental chemicals on the endocrine system in children

Rogan

Ragan

2007

International Journal of Hygiene and Environmental Health

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Pollutant chemicals that are widespread in the environment can affect endocrine function in laboratory experiments and in wildlife. Although human beings are commonly exposed to such pollutant chemicals, the exposures are generally low and clear effects on endocrine function from such exposures have been difficult to demonstrate. Human data including both exposure to the chemical agent and the endocrine outcome are reviewed here, including age at weaning, age at puberty, anogenital distance, and sex ratio at birth, and the strength of the evidence discussed. Although endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real.

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“…Other studies have examined the exposure to phthalate esters (Colon et al, 2000) and topical application of lavender and tea tree oils (Henley et al, 2007). A positive relation between body fat and the onset of puberty is often pointed out (Herman-Giddens et al, 1997; Berkey et al, 2000).…”

Section: Precocious Puberty As a Disease: An Analysis Of Conceptualizmentioning

confidence: 99%

Risky, early, controversial. Puberty in medical discourses

Cozzi

Vinel

2015

Social Science & Medicine

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Identification of Phthalate Esters in the Serum of Young Puerto Rican Girls with Premature Breast Development

Cited by 100 publications

References 9 publications

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Analysis of phthalates via HPLC-UV in environmental water samples after concentration by solid-phase extraction using ionic liquid mixed hemimicelles

Some evidence of effects of environmental chemicals on the endocrine system in children

Risky, early, controversial. Puberty in medical discourses

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