Identification of Periopathogenes from Dental Plaque in Periodontal Patients with PCR Technique and Their Association with Composite Interleukin-1 Genotype

Stojanovska, Aneta Atanasovska; Todoroska, Saska; Поповска, Мирјана; Muratovska, Ilijana; Bedzeti, Linda Zendeli

doi:10.2478/prilozi-2019-0019

Cited by 1 publication

(1 citation statement)

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“…Interleukin 1 genes Positivity for 'composite genotype' (IL1 +) was defined as the presence of at least one copy of 'allele 2' for SNPs IL1B rs 1,143,634 (previously reported as IL1B + 3953 or + 3954) and IL1 A rs 1,800,587 (previously reported as IL1A -889). The present review identified two studies on IL1 composite genotype [24,25].…”

Section: Candidate Gene Studiesmentioning

confidence: 99%

Periodontal infectogenomics: a systematic review update of associations between host genetic variants and subgingival microbial detection

et al. 2022

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Objective The aim of this study was to systematically update the evidence for associations between host genetic variants and subgingival microbial detection and counts. Materials and methods Following a previous systematic review (Nibali et al. J Clin Periodontol 43(11): 889-900, 15), an update of a systematic search of the literature was conducted in Ovid Medline, Embase, LILACS, and Cochrane Library for studies reporting data on host genetic variants and detection of microbes subgingivally published in the last 6 years. Results A total of 19 studies were included in the review, from an initial search of 2797 titles. Studies consisted mainly of candidate gene studies and of one genome-wide analysis. A total of 62 studies were considered for summary findings, including 43 identified in the previous systematic review of studies published up to 2015. Meta-analyses were done when appropriate including both papers in the original review and in the update. Meta-analyses revealed lack of associations between IL1 composite genotype and subgingival detection of Aggregatibacter acinomycetemcomitans, Poprhyromonas gingivalis, Tannerella forsythia, Treponema denticola, and Prevotella intermedia. Promising evidence is emerging from other genetic variants and from sub-analyses of data from genome-association studies. Among other studies with candidate-gene, target SNPs were mainly within the IL10, IL6, IL4, IL8, IL17A, and VDR gene. Conclusions IL1 composite genotype does not seem to be associated with subgingival microbial detection. Promising associations should be pursued by future studies, including studies employing -OMICS technologies. Clinical relevance A better knowledge of which host genetic variant predispose to subgingival microbial colonization and to the development of progression of periodontal disease could potentially help to better understand periodontal disease pathogenesis and help with its management.

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Section: Candidate Gene Studiesmentioning

confidence: 99%