Identification of Pathways and Genes Associated with Cold and Hot Properties of Chinese Materia Medica Based on Bioinformatics Analysis

Wang, Yue; Zhou, Lu; Zhang, Shujing; Liu, Zhenzhu; Li, Caiyan; Gao, Yue; Sun, Yi-Chih; Zheng, Fengjie; Li, Yu-Hang

doi:10.1016/j.phytol.2020.05.012

Cited by 1 publication

(3 citation statements)

References 23 publications

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“…The following components, highly enriched in the CG, were named as cold components (CCs): chlorogenic acid, ethyl caffeate, gentiopicroside, and artemisinin. We excluded anhydroicaritin from the CCs because it was previously classified as a hot component in a study [ 15 ].…”

Section: Resultsmentioning

confidence: 99%

“…A previous study also analyzed the same dataset under the assumption that the major ingredients of herbs are representative of their effects [ 15 ]. However, a herb contains a variety of components in addition to its major ingredients.…”

Section: Discussionmentioning

confidence: 99%

“…The cold property was associated with promoting arginine and proline metabolism, tryptophan metabolism, and ATP storage and generation, while the hot property had the opposite effect. Based on the gene expression data previously obtained from MCF7 cells treated with herbal ingredients [ 14 ], Wang et al identified the pathways and genes associated with the hot and cold properties based on the active ingredients of 6 cold- and 6 hot-temperament herbs [ 15 ]. Differences between cold and hot properties were enriched in the endocrine system, cell proliferation and apoptosis, and hemorheology.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Analysis of the Molecular Mechanisms of Cold and Hot Properties of Herbal Medicines

Park

Baek

Ban

et al. 2022

Plants

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Effective treatments for patients experiencing temperature-related symptoms are limited. The hot and cold effects of traditional herbal medicines have been utilized to treat and manage these symptoms, but their molecular mechanisms are not fully understood. Previous studies with arbitrarily selected herbs and ingredients may have produced biased results. Here, we aim to systematically elucidate the molecular mechanisms of the hot and cold properties of herbal medicines through an unbiased large-scale investigation of herbal ingredients, their target genes, and the transcriptome signatures induced by them. Using data regarding 243 herbs retrieved from two herbal medicine databases, we statistically identify (R)-Linalool, (-)-alpha-pinene, peruviol, (L)-alpha-terpineol, and cymol as five new hot-specific ingredients that share a common target, a norepinephrine transporter. However, no significant ingredients are cold-specific. We also statistically identify 14 hot- and 8 cold-specific new target genes. Pathway enrichment analysis of hot-specific target genes reveals the associated pathways including neurotransmitter reuptake, cold-induced thermogenesis, blood pressure regulation, adrenergic receptor signaling, and cation symporter activity. Cold-specific target genes are associated with the steroid pathway. Transcriptome analysis also shows that hot herbs are more strongly associated with coagulation and synaptic transmission than cold herbs. Our results, obtained from novel connections between herbal ingredients, target genes, and pathways, may contribute to the development of pharmacological treatment strategies for temperature-related pain using medicinal plants.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%