Identification of Pathogenic<i>Leptospira</i>Strains in Tissues of a Premature Foal by Use of Polymerase Chain Reaction Analysis

Léon, Albertine; Pronost, Stéphane; Tapprest, Jackie; Foucher, N.; Blanchard, B.; André‐Fontaine, Geneviève; Laugier, Claire; Fortier, Guillaume; Leclercq, Roland

doi:10.1177/104063870601800216

Cited by 44 publications

(33 citation statements)

References 21 publications

(36 reference statements)

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“…Leptospirosis, in addition to being the most common bacterial zoonosis worldwide (Lau et al 2010), is also classified as an emerging infectious disease (Bolin. 1996, Leon et al 2006. The infection usually results from direct transmission via contaminated urine, placental fluids, and tissues of affected animals or indirectly from a contaminated environment (Baverud et al 2009).…”

Section: Introductionmentioning

confidence: 99%

A study of leptospirosis in South African horses and associated risk factors

Simbizi

Saulez²,

Potts

et al. 2016

Preventive Veterinary Medicine

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between potential risk factors and both seropositive horses to the predominant serovar Bratislava and to Leptospira spp were statistically evaluated using univariable analysis and multivariable logistic regression models.Adult horses admitted to each equine hospital and horses seen on ambulatory service for various purposes were included in the study. Severely-ill, chronically infected, and horses with underlying immunosuppressive conditions were excluded from sampling, to control for potential bias.A total of 663 horse sera were collected and tested against a panel of 24 leptospiral serovars using the microscopic agglutination test. The most predominant serovars in Gauteng were The apparent prevalence to one or more serovars of Leptospira spp at a serum dilution of 1:100 in Gauteng, KwaZulu-Natal and Western Cape Provinces was 49%; 37% and 32% respectively. The true prevalence was calculated for each province taking into account the clustering effect during the sampling and was found to be between 24-74% in Gauteng; 26-39% in the Western Cape and 20-54% in KwaZulu-Natal.iv Nooitgedacht (South African horse breed) horses were found to be at greater risk of being seropositive to both serovar Bratislava (OR=5.08) and Leptospira spp (OR=6.3). Similarly, horses residing on properties with forestry in the vicinity were found to be at greater risk of being seropositive to both serovar Bratislava (OR=9.3) and Leptospira spp (OR=5.2). This study has shown that a high proportion of horses in South Africa are exposed to a wide range of serovars, inferring a complex epidemiology. It also describes for the first time new serovars of Leptospira in South African horses that have not previously been reported.v

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Section: Introductionmentioning

confidence: 99%

A study of leptospirosis in South African horses and associated risk factors

Simbizi

Saulez²,

Potts

et al. 2016

Preventive Veterinary Medicine

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“…Ως κλινικές εκδηλώσεις της χρόνιας μορφής μπορούν να θεωρηθούν οι πιο ήπιες εκδηλώσεις της αντίστοιχης οξείας μορφής, καθώς επίσης οι αποβολές και γεννήσεις νεκρών ή ασθενικών νεογνών (Vemulapalli et al 2005, Bomfim and Koury 2006, Leon et al 2006, Szeredi and Haake 2006, Saglam et al 2008. Επίσης, κλινική εκδήλωση της χρόνιας μορφής θεω ρείται και η χαρακτηριστική πανοφθαλμίτιδα των σαρ κοφάγων (Townsend et al 2006), του ανθρώπου (Gupta et al 2007) και των ιπποειδών (Faber et al 2000).…”

Section: παθογενετικοι μηχανισμοί του γένους Leptospiraunclassified

“…Αυτή η εντόπιση, αλλά και οι ιδιαιτερότητες απομό νωση της λεπτόσπειρας δυσκολεύουν πολύ την εργα στηριακή διερεύνηση της λοίμωξης (Vemulapalli et al 2005, Szeredi and Haake 2006, Bomfim and Koury 2006, Leon et al 2006, Ortega-Pacheco et al 2008, Saglam et al 2008. Για τους ίδιους λόγους είναι δύσκολο να εντοπιστούν τα ζώα φορείς, που μπορεί να παραμείνουν αφανείς δεξαμενές του μικροοργα νισμού, αλλά και να νοσήσουν, αν κάποιοι παράγοντες καταπόνησης επιτρέψουν τον πολλαπλασιασμό του βακτηρίου.…”

Section: παθογενετικοι μηχανισμοί του γένους Leptospiraunclassified

Leptospirosis: An important re-emerging infection of animals and man

Μπισιασ)¹,

Kritas

Burriel

et al. 2017

J Hellenic Vet Med Soc

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Leptospirosis, a re-emerging infection of animals and man, is caused by one of 200 serotypes of Leptospira spp. The genus is currently divided into eight pathogenic species, infecting various animal species and man, either clinically or subclinically. Natural hosts of the microorganism are traditionally, but not exclusively, considered to be rodents. Infected animals excrete Leptospira in the environment, where it may remain for long periods of time, especially if temperatures are about 25°C. The reportedprevalence of infected animals from around the world is between 2% and 46%. In Greece, recent reports show a seropositivity among abortion cases of small ruminants around 25%, while the relevant percentage among apparently healthy food producing animals is between 5.7% and 16.2%. The most prevalent serotypes were Bratislava, Australis and Copenhageni, depending on the animal species. There is a need for more systematic study of the infection in Greece (especially with the possibility of the expected climatic changes to result in a temperature rise).

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“…Les chevaux atteints présentent des troubles chroniques de la reproduction (Léon et al 2006) et / ou une uvéite causée par la présence des leptospires et des anticorps spécifiques dans les chambres oculaires ; cette uvéite laisse l'animal très sensible à la lumière et peut évoluer vers la cécité.…”

Section: La Leptospirose Chez Les Animaux Domestiquesunclassified

La leptospirose : Les défis actuels d'une ancienne maladie

Ristow¹

2007

bavf

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La leptospirose, maladie infectieuse atteignant l'homme et les animaux, est considérée comme la zoonose la plus répandue dans le monde ; chaque année, elle est responsable de graves épidémies dans les pays tropicaux et en voie de développement. Son agent causal, Leptospira interrogans, est un spirochète de forme hélicoïdale, extrêmement mobile. Le tableau clinique varie du fait de la diversité du genre Leptospira et d'une épidémiologie complexe. Les leptospiroses animales touchent plusieurs espèces de mammifères qui développent majoritairement des formes chroniques de la maladie et deviennent ainsi des réservoirs de l'agent infectieux. La forme humaine ou maladie de Weil, dont le taux de mortalité est élevé, est provoquée par les leptospires du sérogroupe Icterohaemorrhagiae. La vaccination de l'homme et des animaux a des effets limités car les vaccins utilisés sont spécifiques du sérovar et n'offrent qu'une protection de courte durée. Le test de microagglutination (MAT) pré-sente des inconvénients comme l'impossibilité d'identifier la phase précoce de la maladie mais des progrès diagnostiques sont encore envisageables. En effet, le récent séquençage du génome des leptospires et le développement d'outils génétiques spécifiques marquent le début de l'ère post-géno-mique dans la recherche sur les spirochètes. Nos efforts portent actuellement sur la compréhension des mécanismes de virulence des leptospires, ainsi que sur la mise au point de tests diagnostiques et de vaccins plus performants. L'Unité de Biologie des Spirochètes, de l'Institut Pasteur de Paris, vient d'identifier un facteur de virulence des leptospires, une protéine de la famille OmpA, Loa22, exposée à la surface de la bactérie. La protéine Loa22 est un candidat pour le développement d'un vaccin. Leptospirosis is an infectious disease which affects man and animals, and is considered as the most common zoonosis worldwide. Every year, it is responsible for serious epidemics in tropical and developing countries. The pathogen is Leptospira interrogans, an extremely mobile and helicoidal spirochete. The clinical presentation of leptospirosis varies due to the diversity within the genus

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Identification of PathogenicLeptospiraStrains in Tissues of a Premature Foal by Use of Polymerase Chain Reaction Analysis

Cited by 44 publications

References 21 publications

A study of leptospirosis in South African horses and associated risk factors

A study of leptospirosis in South African horses and associated risk factors

Leptospirosis: An important re-emerging infection of animals and man

La leptospirose : Les défis actuels d'une ancienne maladie

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