“…The database search process, excluded and included articles, as well as reasons for the exclusion are shown in Figure 1. Twenty-one articles were selected for full text review and abstracted, with information (disease, sample size, saliva type collected, selection of controls, analytical method utilized, and biomarkers identified) documented in Tables 1 and 2 and Supplementary Table 1 (Dowling et al, 2008;Fleissig et al, 2009;Giusti et al, 2007aGiusti et al, , 2007bHirtz et al, 2006;Hu et al, 2007bHu et al, , 2007cHu et al, , 2008Huang, 2004;Imanguli et al, 2007;Ohsiro et al, 2007;Peluso et al, 2007;Preza et al, 2009;Rao et al, 2009;Ryu et al, 2006;Streckfus et al, 2006Streckfus et al, , 2008Vitorino et al, 2006;Wu et al, 2009aWu et al, , 2009bYang et al, 2006). This systematic review is the first to evaluate the MSbased proteomic studies that utilized saliva to define biomarkers related to specific diseases.…”