Identification of Organic Compounds. I. Chlorosulfonic Acid as a Reagent for the Identification of Aryl Halides

Abstract

wave length examined, with the possible exception of 2894 A.3. The activation by 2894 Á. appears to be intermediate between that of 2967 Á. and the other wave lengths tested.4. No demonstrable antirachitic properties were produced by irradiation of 7-dehydrocholesterol in ether by ultraviolet of 3130 Á.5. The superior effectiveness of 2967 Á. in antirachitic activation of 7-dehydrocholesterol parallels the significant superiority of this wave length in inducing healing upon direct irradiation of depilated rachitic rats, which supports the hypothesis that 7-dehydrocholesterol is a significant precursor of vitamin D in the skin.Cambridge, Mass.

Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides

“…2-Bromobenzenesulfonyl chloride (1a) and 2-bromosulfonyl amide (4a) were prepared by a procedure of Bahlman. [15] 2,5-Dibromosulfonyl chroride (1c), 2,5-dibromobenzenesulfonyl amide (4c), and 2,4-dibromobenzenesulfonyl (4d) amide were prepared using the procedure of Huntress and Carten, [16] and 2,4-dibromobenzenesulfonyl (1d) chloride was prepared by the procedure of Pezold et al [17] 2-Bromo-4-carbomethoxybenzenesulfonyl Chloride (1b)…”

The SRN1 reactions of 1,8-diiodonaphthalene

“…Lithium aluminum hydride (6.0 g) was placed in a Soxhlet apparatus whose delivery system was protected by dry glass wool rather than the usual Soxhlet thimble. A solution of mesitylenesulfonyl chloride (10.0 g, 46 mmol) prepared by the method of Carten and Huntress 20 in anhydrous tetrahydrofuran (300 mL) was heated under reflux whilst attached to the Soxhlet system for 3 h. On completion of the reaction the excess of lithium aluminum hydride was quenched by addition of an EtOH/benzene solution (50%, 160 mL). The lithium and aluminum salts were dissolved in an excess of H 2 SO 4 (10%), and a further amount of benzene (40 mL) was added.…”

Novel Synthesis of Mafenide and Other Amino Sulfonamides by Electrochemical Reduction of Cyano Sulfonamides

“…Through a soln. of the nitrile 2 (10 mmol) [1] [12] [13] in anh. MeOH (40 ml) containing MeONa (0.1 mol) and freshly prepared Raney Ni (1.0 g) [14], O 2 -free N 2 gas was bubbled for 10 -15 min.…”