2002
DOI: 10.1136/gut.51.1.65
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Identification of objective pathological prognostic determinants and models of prognosis in Dukes' B colon cancer

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Cited by 245 publications
(256 citation statements)
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“…Principal among these is nodal disease which indicates a high likelihood of disease recurrence and the need for adjuvant therapy 3 21 . In patients with no evidence of nodal disease, other pathological criteria have been proposed by Shepherd's group which identify patients at high risk of recurrence and which are now routinely reported 5 . These include vascular invasion, peritoneal involvement, margin involvement and tumour perforation.…”
Section: Discussionmentioning
confidence: 99%
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“…Principal among these is nodal disease which indicates a high likelihood of disease recurrence and the need for adjuvant therapy 3 21 . In patients with no evidence of nodal disease, other pathological criteria have been proposed by Shepherd's group which identify patients at high risk of recurrence and which are now routinely reported 5 . These include vascular invasion, peritoneal involvement, margin involvement and tumour perforation.…”
Section: Discussionmentioning
confidence: 99%
“…These include vascular invasion, peritoneal involvement, margin involvement and tumour perforation. These criteria have been combined in a score, the Petersen Index (PI), which reliably predicts poorer cancer-specific outcome in Dukes' B colon cancer 5 . These findings have recently been validated in colorectal cancer by Quirke's group 10 .…”
Section: Discussionmentioning
confidence: 99%
“…Quelle: [ In Studien gingen gewisse Risikosituationen wie ein T4-Tumor, eine Tumorperforation und/oder Operation unter Notfallbedingungen sowie eine zu geringe Anzahl untersuchter Lymphknoten mit einer schlechteren Prognose einher [891,892]. Eine retrospektive Untersuchung an 1306 Patienten mit einem Stadium-IITumor zeigte in einer multivariaten Analyse, dass die Kategorie T4 mit einem schlechten krankheitsfreien Überleben assoziiert war (HR 1,75) [893].…”
Section: Level Of Evidence 1aunclassified
“…Deshalb sollte eine Therapie in diesem Stadium zumindest in Betracht gezogen werden [751], in jedem Fall sollten die Vorteile und Risiken einer solchen Therapie mit dem Patienten besprochen werden. [756,757]. Eine neuere retrospektive Untersuchung an 1306 Patienten mit einem Stadium-II-Tumor zeigte in einer multivariaten Analyse, dass die Kategorie T4 mit einem schlechten krankheitsfreien Überleben assoziiert war (HR 1,75) [758].…”
Section: Gcp Starker Konsensunclassified