Identification of Novel Vaccine Candidates against<i>Campylobacter</i>through Reverse Vaccinology

Campylobacter jejuni is the leading cause of bacteria-derived gastroenteritis worldwide. In the developed world, Campylobacter is usually acquired by consuming under-cooked poultry, while in the developing world it is often obtained through drinking contaminated water. Once consumed, the bacteria adhere to the intestinal epithelium or mucus layer, causing toxin-mediated inhibition of fluid reabsorption from the intestine and invasion-induced inflammation and diarrhea. Traditionally, severe or prolonged cases of campylobacteriosis have been treated with antibiotics; however, overuse of these antibiotics has led to the emergence of antibiotic-resistant strains. As the incidence of antibiotic resistance, emergence of post-infectious diseases, and economic burden associated with Campylobacter increases, it is becoming urgent that novel treatments are developed to reduce Campylobacter numbers in commercial poultry and campylobacteriosis in humans. The purpose of this review is to provide the current status of present and proposed treatments to combat Campylobacter infection in humans and colonization in animal reservoirs. These treatments include anti-Campylobacter compounds, probiotics, bacteriophage, vaccines, and anti-Campylobacter bacteriocins, all of which may be successful at reducing the incidence of campylobacteriosis in humans and/or colonization loads in poultry. In addition to reviewing treatments, we will also address several proposed targets that may be used in future development of novel anti-Campylobacter treatments.

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“…Total OMPs (Annamalai et al, 2013) and fusion proteins (Neal-McKinney et al, 2014) have also been evaluated (Meunier et al, 2016b). …”

Section: Campylobacter Vaccines For Poultry and Humansmentioning

confidence: 99%

“…Other Campylobacter species can also cause disease, but they are rarely involved (Meunier et al, 2016b). Human infection can occur following ingestion of as few as 500 Campylobacter cells; however, the sample size in this particular study was small ( n = 1) (Robinson, 1981).…”

Section: Introductionmentioning

confidence: 99%

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

2017

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“…Most of the time, vaccine candidates are expressed in biological systems that are diferent from the original source; in that case, the three-dimensional (3D) structure of the protein could be changed or diicult to purify if it has a transmembrane helix, due to diferences in membrane structure [21]. The low transmembrane helix number is a major characteristic for the selection of a vaccine candidate.…”

Section: Transmembrane Helixmentioning

confidence: 99%

The Impact of Bioinformatics on Vaccine Design and Development

María¹,

Arturo²,

Alicia³

et al. 2017

Vaccines

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Vaccines are the pharmaceutical products that ofer the best cost-beneit ratio in the prevention or treatment of diseases. In that a vaccine is a pharmaceutical product, vaccine development and production are costly and it takes years for this to be accomplished. Several approaches have been applied to reduce the times and costs of vaccine development, mainly focusing on the selection of appropriate antigens or antigenic structures, carriers, and adjuvants. One of these approaches is the incorporation of bioinformatics methods and analyses into vaccine development. This chapter provides an overview of the application of bioinformatics strategies in vaccine design and development, supplying some successful examples of vaccines in which bioinformatics has furnished a cuting edge in their development. Reverse vaccinology, immunoinformatics, and structural vaccinology are described and addressed in the design and development of speciic vaccines against infectious diseases caused by bacteria, viruses, and parasites. These include some emerging or re-emerging infectious diseases, as well as therapeutic vaccines to ight cancer, allergies, and substance abuse, which have been facilitated and improved by using bioinformatics tools or which are under development based on bioinformatics strategies.

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“…Since then, new computational tools have been used for selection of vaccine targets, see. [26][27][28][29][30][31][32][33][34] Pappalardo et al 35 present a survey of several computational modeling techniques applied to vaccinology science. Most of the works focus on using computational science to predict epitopes, as the work of Lafuente and Reche,…”

Section: Introductionmentioning

confidence: 99%

Mathematical modeling based on ordinary differential equations: A promising approach to vaccinology

Bonin

Fernandes

Santos

et al. 2016

Human Vaccines & Immunotherapeutics

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New contributions that aim to accelerate the development or to improve the efficacy and safety of vaccines arise from many different areas of research and technology. One of these areas is computational science, which traditionally participates in the initial steps, such as the pre-screening of active substances that have the potential to become a vaccine antigen. In this work, we present another promising way to use computational science in vaccinology: mathematical and computational models of important cell and protein dynamics of the immune system. A system of Ordinary Differential Equations represents different immune system populations, such as B cells and T cells, antigen presenting cells and antibodies. In this way, it is possible to simulate, in silico, the immune response to vaccines under development or under study. Distinct scenarios can be simulated by varying parameters of the mathematical model.As a proof of concept, we developed a model of the immune response to vaccination against the yellow fever. Our simulations have shown consistent results when compared with experimental data available in the literature. The model is generic enough to represent the action of other diseases or vaccines in the human immune system, such as dengue and Zika virus. KEYWORDS computational science; computational modeling; computational immunology; computational vaccinology; immune system; ordinary differential equations; yellow fever

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Identification of Novel Vaccine Candidates againstCampylobacterthrough Reverse Vaccinology

Cited by 76 publications

References 48 publications

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

Current and Potential Treatments for Reducing Campylobacter Colonization in Animal Hosts and Disease in Humans

The Impact of Bioinformatics on Vaccine Design and Development

Mathematical modeling based on ordinary differential equations: A promising approach to vaccinology

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