Identification of novel step‐up regimen of intralesional triamcinolone acetonide in scalp alopecia areata based on a double‐blind randomized controlled trial

Abstract

Although intralesional triamcinolone acetonide (TA) is the most commonly prescribed treatment for localized alopecia areata (AA), the literature regarding the optimal concentration for attaining better efficacy with the most acceptable side effects is scarce. To compare hair regrowth and local side effects of various concentrations of intralesional TA in scalp AA using clinical and dermoscopic parameters. A double‐blind randomized control trial with four treatment groups (10, 5, 2.5 mg/ml TA and normal saline [NS]) was conducted between March 2018 and August 2019. After recruitment, each AA patch was divided into quadrants and randomized before first injection. Injections were given and outcome parameters were analyzed every 4‐weekly till 12‐weeks. Statistical analysis was done by the R software employing generalized estimation equation. P‐value <.05 was considered significant. Out of 105‐patients (168‐AA patches), 75‐patients (121‐patches) completed the study. Hair regrowth scale of all TA concentrations was better than NS group (P < .001). Other parameters such as quadrants with poor clinical response and dermoscopic disease activity signs were also favorable in TA groups in comparison to NS. However the evidence of atrophy and telangiectasia was maximum in 10 mg/mL group. 10 mg/mL TA showed a comparatively better response at the cost of increased adverse effects. Based on the clinical benefit and adverse risk assessment from our study, it may be better to start with 2.5 mg/mL intralesional TA in limited scalp AA patients. It can be implied that the concentration of TA can be increased as a step‐up regimen based on the serial clinical and dermoscopic response.

Platelet-Rich Plasma in Alopecia Areata—A Steroid-Free Treatment Modality: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

“…The strength of the effect of TrA can be dose-dependent: RCTs investigating the most effective dilution of TrA showed that the 10 mg/mL dose achieved the best therapeutic response; however, due to the dose-dependent increasing risk of adverse effects, it is advised to start the treatment with lower doses [ 28 , 29 ]. Two of the four studies included in our meta-analysis used 5 mg/mL TrA, and two studies used 10 mg/mL TrA as a comparator [ 19 ].…”

“…Future RCTs should also focus on the comparison of PRP with different doses of TrA, since, while high doses of TrA lead to better improvement, they may also increase the risk of adverse effects [ 28 , 29 ]. A steroid-free treatment option, such as PRP, as a first-choice treatment could be beneficial, even if it shows slower improvement.…”