Identification of novel pyrazole acid antagonists for the EP1 receptor

1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes

“…20 N-Aryl derivatives of 1 such as the N-substituted benzyl derivative 2 and the pyrazole organotin(IV) ester 3 also display desirable physicochemical properties. 21,22 Like the…”

Synthetic Routes to Pyrazole‐3(5)‐carboxylates

“…5‐Alkyl‐pyrazole‐3‐carboxylates 3 were synthesized via Claisen condensation of diethyl oxalate with alkyl methyl ketones 1 to give the corresponding 2,4‐diketoesters 2 . Subsequent cyclization with hydrazine hydrochloride afforded the pyrazole‐3‐carboxylic acid ethyl esters 3 (Scheme ) .…”

Synthesis, Characterization and Crystal Structure of Some Novel 1‐(3,5‐Dimethyl‐1H‐pyrazol‐1‐yl)‐3‐(substituted anilino)propan‐1‐ones

“…3 Pyrazole chemotype is a structural motif of several highly potent inhibitors against coagulation factor Xa 4 amongst them, Rivaroxaban 5 and Apixaban 6 were selected for clinical development for the prevention and treatment of thrombotic diseases. Pyrazole derivatives with anticonvulsant, sodium channel blocker, 7 antimycobacterial, 8 herbicidal, 9 hypoglycemic, 10 hypolipidemic, 11 antiamoebic 12 and antidepressant activities 13 have been reported. Furthermore, pyrazole 3-carboxylates were also identified as selective antagonist subtype 1PGE2 receptors.…”