Identification of novel piRNAs in bladder cancer

Chu, Haiyan; Hui, Gaoyun; Lin, Yuan; Shi, Danni; Wang, Yubang; Du, Mulong; Zhong, Dongyan; Ma, Lan; Tong, Na; Qin, Chao; Chen, Yin; Zhang, Zhengdong; Wang, Meilin

doi:10.1016/j.canlet.2014.10.004

Cited by 117 publications

(108 citation statements)

References 43 publications

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“…PIWI family proteins have been shown to be aberrantly expressed and associated with poor prognosis in ovarian, colorectal, gastric, hepatocellular, esophageal, and pancreatic cancers (13)(14)(15)(16)(17)(18), and piRNA expression has been observed in bladder, colon, lung, cervical, breast, hepatocellular, and gastric cancers (19)(20)(21)(22)(23)(24). Our recent study also identified a genetic variant in a mature piRNA sequence that is associated with breast cancer risk (25).…”

Section: Introductionmentioning

confidence: 68%

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Jacobs

Qin

Lerro

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: PIWI-interacting RNAs (piRNAs), the largest class of noncoding RNAs in mammals, cooperate with PIWI proteins to safeguard the genome from insertional mutations during germline development. Although a growing number of studies have linked the PIWI-piRNA pathway to carcinogenesis, the role of piRNAs in glioma has not been explored.Methods: Utilizing directly measured and imputed genotypes from the GliomaScan genome-wide association study (1,840 cases and 2,401 controls), genetic variants in 1,428 piRNAs were analyzed for association with glioma risk. In vitro assays were performed to interrogate the functional impact of a top identified piRNA and its variant allele.Results: Variants in five piRNAs were considered to be associations of interest and four of these showed narrow clusters of enhanced association signals surrounding the index variant. Functional analyses of one of these piRNAs, piR-598, revealed that transfection of the wild-type piRNA impacted expression of

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Section: Introductionmentioning

confidence: 68%

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

Jacobs

Qin

Lerro

et al. 2016

Cancer Epidemiology, Biomarkers &Amp; Prevention

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“…Seventy to eighty percent of all these piRNA sequences have been found on unique genomic loci with the remaining 20-30 % on multiple genomic loci. Early studies on different tumor types like gastric, colon, lung, and breast cancer showed that dysregulated piRNAs can be involved, just like miRNAs, in cancerogenesis [19][20][21][22][23][24][25]. However, in ccRCCs as the most frequent RCC, no studies have yet been conducted in view of the profile of piRNAs and their potential use as diagnostic and prognostic biomarkers in this cancer.…”

Section: Introductionmentioning

confidence: 99%

773 Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas

Ralla¹,

Magheli²,

Kempkensteffen³

et al. 2015

European Urology Supplements

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Background: Piwi-interacting RNAs (piRNAs) are small RNAs of 27-30 nucleotides mapping to transposons or clustering in repeat genomic regions. Preliminary studies suggest an important role in cancerogenesis. This study is the first one investigating their prognostic impact in clear cell renal cell cancer (ccRCC) patients. Methods: Three piRNAs (piR-30924, piR-57125, and piR-38756) selected on the basis of initial piRNA microarray analyses were determined using RT-qPCR in non-metastatic (n = 76) and metastatic (n = 30) ccRCC tissue at the time of nephrectomy in comparison to normal renal tissue (n = 77) and tissue from distant ccRCC metastases (n = 13). Primary clinical end points were recurrence-free and overall survival.

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“…However, a number of reports have demonstrated the expression of mRNAs encoding components of the piRNA pathway in somatic cell types (Ross et al 2014;Chu et al 2015). In particular, mRNAs for PIWI family proteins are often detected in stem cell populations, although there is still little information on whether these proteins are loaded with piRNAs or whether they perform a function in those cells.…”

mentioning

confidence: 99%

“…Among the CTAs, PIWI proteins and other components of the piRNA pathway have been detected in a number of different tumor types, including those of the breast, colon, and pancreas (for review, see Ross et al 2014). In bladder and breast cancer, ∼100 different loci produce small RNAs with features reminiscent of piRNAs (Hashim et al 2014;Chu et al 2015). However, their physical association with Piwi was not demonstrated and their biological function was not examined.…”

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confidence: 99%

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Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway

et al. 2016

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Germline genes often become re-expressed in soma-derived human cancers as “cancer/testis antigens” (CTAs), and piRNA (PIWI-interacting RNA) pathway proteins are found among CTAs. However, whether and how the piRNA pathway contributes to oncogenesis in human neoplasms remain poorly understood. We found that oncogenic Ras combined with loss of the Hippo tumor suppressor pathway reactivates a primary piRNA pathway in Drosophila somatic cells coincident with oncogenic transformation. In these cells, Piwi becomes loaded with piRNAs derived from annotated generative loci, which are normally restricted to either the germline or the somatic follicle cells. Negating the pathway leads to increases in the expression of a wide variety of transposons and also altered expression of some protein-coding genes. This correlates with a reduction in the proliferation of the transformed cells in culture, suggesting that, at least in this context, the piRNA pathway may play a functional role in cancer.

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Identification of novel piRNAs in bladder cancer

Cited by 117 publications

References 43 publications

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

PIWI-Interacting RNAs in Gliomagenesis: Evidence from Post-GWAS and Functional Analyses

773 Piwi-interacting RNAs as novel prognostic markers in clear cell renal cell carcinomas

Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway

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