Identification of novel heavy metal detoxification proteins in Solanum tuberosum: Insights to improve food security protection from metal ion stress

He, Guandi; Tian, Weijun; Qin, Lijun; Meng, Lulu; Wu, Danxia; Huang, Yun; Li, Dandan; Zhao, Degang; He, Tengbing

doi:10.1016/j.scitotenv.2021.146197

Cited by 23 publications

(16 citation statements)

References 85 publications

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“…The potato, an edible tuber, is the fourth most important food crop in the world. Many gene families have been identified and analyzed in potato, such as MYB gene family ( Sun et al, 2019 ), StGRAS ( Wang et al, 2019 ), heat shock proteins20 (Hsp20) ( Zhao et al, 2018 ), HMA ( He et al, 2020 ), ATP-binding cassette (ABC) ( He et al, 2021 ), and so on. Recently, Li et al (2019) and Chen Q. et al (2020) conducted a preliminary identification of the MATE gene family in potatoes.…”

Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification of MATE Gene Family in Potato (Solanum tuberosum L.) and Expression Analysis in Heavy Metal Stress

Huang

Tian

et al. 2021

Front. Genet.

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A genome-wide identification and expression analysis of multidrug and toxic compound extrusion (MATE) gene family in potato was carried out to explore the response of MATE proteins to heavy meta stress. In this study, we identified 64 MATE genes from potato genome, which are located on 12 chromosomes, and are divided into I–IV subfamilies based on phylogenetic analysis. According to their order of appearance on the chromosomes, they were named from StMATE1–64. Subcellular location prediction showed that 98% of them are located on the plasma membrane as transporters. Synteny analysis showed that five pairs of collinearity gene pairs belonged to members of subfamily I and subfamily II had two pairs indicating that the duplication is of great significance to the evolution of genes in subfamilies I and II. Gene exon–intron structures and motif composition are more similar in the same subfamily. Every StMATE gene contained at least one cis-acting element associated with regulation of hormone transport. The relative expression levels of eight StMATE genes were significantly upregulated under Cu2+ stress compared with the non-stress condition (0 h). After Cd2+ stress for 24 h, the expression levels of StMATE33 in leaf tissue were significantly increased, indicating its crucial role in the process of Cd2+ stress. Additionally, StMATE18/60/40/33/5 were significantly induced by Cu2+ stress, while StMATE59 (II) was significantly induced by Ni2+ stress. Our study initially explores the biological functions of StMATE genes in the regulation of heavy metal stress, further providing a theoretical basis for studying the subsequent molecular mechanisms in detail.

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Section: Introductionmentioning

confidence: 99%

Genome-Wide Identification of MATE Gene Family in Potato (Solanum tuberosum L.) and Expression Analysis in Heavy Metal Stress

Huang

Tian

et al. 2021

Front. Genet.

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“…The transport process does not involve phosphorylation intermediates, and is involved in maintaining renal acid balance, regulating apoptosis and cell cycle, nerve signal transmission and other physiological functions in animals. The structure, function and mechanism of the ABC protein have always been the focus of research [ 32 ]. ABC transporters are composed of two highly hydrophobic transmembrane domains and two intracellular nucleotide binding domains.…”

Section: Membrane Transportersmentioning

confidence: 99%

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

2021

Membranes

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Normal substrate transport and signal transmission are the premise to ensure the health of biological somatic cells. Therefore; a comprehensive understanding of the molecular mechanism of intercellular substrate transport is of great significance for clinical treatment. In order to better understand the membrane protein through its interaction with receptors, to help maintain a healthy cell and the molecular mechanisms of disease, in this paper, we seek to clarify, first of all, the recognition mechanism for different types of membrane protein receptors; pathogen invasion using the transport pathway involved in the membrane; and the latest specific target sites of various kinds of membrane transport carriers; to provide an explanation and summary of the system. Secondly; the downstream receptor proteins and specific substrates of different membrane transporters were classified systematically; the functional differences of different subclasses and their relationship with intracellular transport disorders were analyzed to further explore the potential relationship between cell transport disorders and diseases. Finally, the paper summarizes the use of membrane transporter-specific targets for drug design and development from the latest research results; it points out the transporter-related results in disease treatment; the application prospects and the direction for drug development and disease treatment providing a new train of thought; also for disease-specific targeted therapy, it provides a certain reference value.

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“…Agrarian soils in different parts of the world are slightly/moderately contaminated with HM, which is concerning due to their harmful effect on human health, ecosystem function, and global economic growth ( Shahid et al, 2015 ). HM toxicity hampers normal plant functioning by producing excessive reactive oxygen species (ROS), repressing respiration, photosynthesis, and vascular and enzymatic activities, and disrupting ion homeostasis ( He et al, 2021 ). Plants have complex inherent biological mechanisms to counter the adversities of HM but fail to mitigate them at toxic levels ( Chandrakar et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Abscisic acid: Metabolism, transport, crosstalk with other plant growth regulators, and its role in heavy metal stress mitigation

et al. 2022

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Heavy metal (HM) stress is threatening agricultural crops, ecological systems, and human health worldwide. HM toxicity adversely affects plant growth, physiological processes, and crop productivity by disturbing cellular ionic balance, metabolic balance, cell membrane integrity, and protein and enzyme activities. Plants under HM stress intrinsically develop mechanisms to counter the adversities of HM but not prevent them. However, the exogenous application of abscisic acid (ABA) is a strategy for boosting the tolerance capacity of plants against HM toxicity by improving osmolyte accumulation and antioxidant machinery. ABA is an essential plant growth regulator that modulates various plant growth and metabolic processes, including seed development and germination, vegetative growth, stomatal regulation, flowering, and leaf senescence under diverse environmental conditions. This review summarizes ABA biosynthesis, signaling, transport, and catabolism in plant tissues and the adverse effects of HM stress on crop plants. Moreover, we describe the role of ABA in mitigating HM stress and elucidating the interplay of ABA with other plant growth regulators.

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Identification of novel heavy metal detoxification proteins in Solanum tuberosum: Insights to improve food security protection from metal ion stress

Cited by 23 publications

References 85 publications

Genome-Wide Identification of MATE Gene Family in Potato (Solanum tuberosum L.) and Expression Analysis in Heavy Metal Stress

Genome-Wide Identification of MATE Gene Family in Potato (Solanum tuberosum L.) and Expression Analysis in Heavy Metal Stress

Specifically Targeted Transport of Plasma Membrane Transporters: From Potential Mechanisms for Regulating Cell Health or Disease to Applications

Abscisic acid: Metabolism, transport, crosstalk with other plant growth regulators, and its role in heavy metal stress mitigation

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