Identification of novel biomarkers for lung squamous cell carcinoma

Guttapadu, Ranjitha; Katte, Teesta; Sayeeram, Deepak; Bhatia, Saloni; Abraham, Anika Rachel; Rajeev, Kiran; Siri, Sharadhi; Bommana, Kavitha; Rasalkar, Avinash Arvind; Malempati, Rajyalakshmi; Mustak, Mohammed S.; Narayanan, Prathibha; Reddy, Sirigiri Divijendra Natha

doi:10.1007/s13205-023-03489-z

Cited by 2 publications

(1 citation statement)

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“…Several groups have similarly shown how POLR2H is upregulated in prostate cancer and overexpressed in prostate cancer cells compared to the normal tissue, indicating the potential role of POLR2H as a biomarker for prostate cancer prognosis and diagnosis, as well as a potential drug target [123][124][125]. Furthermore, POLR2H mRNA levels are significantly higher in lung cancer tissue samples compared to normal samples [126], and its high expression significantly correlates with patients' survival in lung squamous cell carcinoma [127,128]. Interestingly, more recent data showed that POLR2H is upregulated in a subset of breast cancer patients resistant to radiotherapy, potentially implicating its role in the acquisition of radio-resistance [129,130].…”

Section: Polr2h/rpb8mentioning

confidence: 97%

Deregulations of RNA Pol II Subunits in Cancer

Muste Sadurni,

Saponaro

2023

Applied Biosciences

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Deregulated transcription is a well-known characteristic of cancer cells, with differentially expressed genes being a common feature of several cancers. Often, deregulated transcription is a consequence of alterations in transcription factors (TFs), which play a crucial role in gene expression and can act as tumour suppressors or proto-oncogenes. In eukaryotic organisms, transcription is carried out by three distinct RNA polymerase complexes: Pol I, Pol II, and Pol III. Pol II, specifically, is responsible for transcribing messenger RNA (mRNA), the protein coding part of the genome, as well as long non-coding RNAs (lncRNAs). While there is considerable research on the impact of specific deregulated transcription factors in cancer development, there is a lack of studies focusing on defects within the RNA polymerase complexes and their subunits. This review aims to shed light in particular on the Pol II complex and highlight the deregulation of its subunits that have a significant impact on tumour development, prognosis, and survival. By providing a comprehensive overview of our current understanding of Pol II subunits in cancer, this review emphasizes the importance of further research in this area. It suggests that exploring these subunits’ deregulations could lead to the identification of valuable biomarkers and potential therapeutic targets, making it a topic of collective interest.

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