Identification of novel benzimidazole derivatives as highly potent AMPK activators with anti-diabetic profiles

Synthesis and Pharmacological Properties of the Benzimidazole Scaffold: A Patent Review

“…Furthermore, when administered chronically, activator compound 45 displayed a dose‐dependent effect in reducing HbA1c levels in the same animal model. These findings suggest that activator compound 45 holds great potential as a therapeutic agent for managing diabetes and warrant further exploration for its clinical applications [75] …”

“…These findings suggest that activator compound 45 holds great potential as a therapeutic agent for managing diabetes and warrant further exploration for its clinical applications. [75] Aroua and their research team embarked on the development of a novel series of benzimidazole ureas with the aim of exploring their potential as antidiabetic agents. Through a series of in vitro assays targeting the α-amylase and αglucosidase enzymes, they uncovered compelling results.…”

Recent Advances in the Anticancer Applications of Benzimidazole Derivatives

“…[35,36] Hence, much research has been reported on the utility of benzimidazole-bearing com-pounds as antifungal, anticancer, antibacterial, antidiabetic, antiproliferative, anthelmintic, antiviral, and antioxidant agents. [37][38][39][40][41][42][43][44] The pharmacological efficiency of benzimidazole derivatives to serve as inhibitor agents of numerous enzymes sheds new light on our findings for treating various incurable diseases, especially different classes of cancers. [45,46] Some renowned benzimidazole-based drugs, including carbendazim, tilomisole, omeprazole, bendamustine, albendazole, and mebendazole, have profoundly influenced the development of modern protocols to combat various diseases (Figure 1).…”

“…Since then, benzimidazoles have been considered a central heterocyclic core due to their broad extent of pharmaceutical and therapeutic applications [35,36] . Hence, much research has been reported on the utility of benzimidazole‐bearing compounds as antifungal, anticancer, antibacterial, antidiabetic, antiproliferative, anthelmintic, antiviral, and antioxidant agents [37–44] . The pharmacological efficiency of benzimidazole derivatives to serve as inhibitor agents of numerous enzymes sheds new light on our findings for treating various incurable diseases, especially different classes of cancers [45,46] .…”

Synthesis, Cytotoxic Activity, Docking and MD Simulation of N,N‐Disubstituted New Benzimidazolium Salts

“…As a noticeable instance, the structural correspondence of 2‐aminobenzimidazole with purine delineated a novel path on the progress of using such frameworks for assorted biological purposes [10] . Since the initial efforts to figure out the biological activity of the benzimidazoles (by Woolley's investigations in 1944), [11] further explorations have been focused on the utility of benzimidazole‐containing products as antifungal, anticancer, antibacterial, antidiabetic, antiproliferative, anthelmintic, antiviral, antitumor and antioxidant agents [12–20] . In this trend, versatile benzimidazole derivatives have attracted growing interest in recent decades and thus, some momentous benzimidazole‐bearing drugs such as carbendazim, omeprazole, bendamustine, albendazole, and mebendazole, have markedly affected the development of modern strategies to combat various diseases [21–25] .…”