Identification of Novel Alkaloids from <i>Portulaca oleracea</i> L. and Characterization of Their Pharmacokinetics and GLP-1 Secretion-Promoting Activity in STC-1 Cells

Su, Weiping; Li, Yanan; Chang, Alan Kueichieh; Sheng, Tongling; Pei, Ying; Li, Jianxin; Li, Haoran; Liu, Kai; Xu, Liuping; Liu, Wenbao; Ai, Jiao; Zhang, Zhicheng; Wang, Yimeng; Jiang, Zhen; Liang, Xiao

doi:10.1021/acs.jafc.3c05191

Cited by 2 publications

(1 citation statement)

References 43 publications

(68 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Food consumption is correlated to variations in the levels of hormones in the body. Nutrients as well as non-nutrient dietary factors stimulate the gut system to modify the release of incretin hormones. , For example, dietary polyphenols elevate blood glucose levels, and also increase insulin levels by stimulating the pancreatic islets . A phenolic compound in olive oil, oleuropein, enhances catecholamine levels (epinephrine and norepinephrine) .…”

Section: Introductionmentioning

confidence: 99%

Bioactive Components in Black Currant Fruit, Red Perilla (Shiso) Leaf, and Chinese Sweet Tea That Enhance Testosterone Production in Leydig Cells and Their Combined Effect in Male Mice

Kato,

Inagaki,

Kayooka

et al. 2024

ACS Food Sci. Technol.

View full text Add to dashboard Cite

Testosterone is a steroid hormone that regulates diverse biological events. Several foods affect testosterone levels in the body, but little is known about the individual components that increase testosterone levels. In this study, black currant (Ribes nigrum) fruit, red perilla (shiso, Perilla frutescens) leaf, and Chinese sweet tea (Rubus suavissimus) enhanced testosterone production in testicular Leydig cells. Delphinidin-3-rutinoside (D3R), rosmarinic acid (RA), and myo-inositol (MI) were identified as bioactive components. Mechanistic analyses suggested that Star plays a role in the bioactivity of D3R and RA, and that the bioactivity of MI is related to Cyp19a1 downregulation. Supplementing the diet with a mixture of black currant fruit extract, red perilla leaf extract, and MI increased serum testosterone levels in male C57BL6/J mice, accompanied by an increased level of Star protein in the testis. These findings add to our knowledge about foods and their components that modulate testosterone levels.

show abstract