Identification of non-coding RNAs and their functional network associated with optic nerve invasion in retinoblastoma

Sun, Jie; Gan, Lu; Ding, Jie; Ma, Ruyun; Qian, Jiang; Xue, Kang

doi:10.1016/j.heliyon.2023.e13813

Cited by 1 publication

(2 citation statements)

References 46 publications

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“…According to Huang et al [45], Circ-E2F3 stimulates the miR-204-5p/ROCK1 pathway, which advances RB. In a study by Li et al [64], the miR-497/WEE1 axis allows TRPM2-AS to function as an oncogenic lncRNA in RB. DANCR serves as a ceRNA that targets miR-34c and miR-613 in the RB, as Wang et al [32] demonstrated, to facilitate MMP-9-mediated progression and metastasis.…”

Section: The Cernas Axes In Rbmentioning

confidence: 99%

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Epigenetic and Posttranscriptional Regulation in Retinoblastoma

Karla¹,

Matilde²,

Meraz-Ríos³

2023

ABB

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The Retinoblastoma 1 (RB1) gene, located on chromosome 13q14 and encodes the tumor-suppressor retinoblastoma protein, is the cause of Retinoblastoma. The mutational inactivation of both gene alleles brings on this cancer. Retinoblastoma (RB) high-risk histopathological characteristics indicate metastasis or local recurrence with rapid progresses following RB1 inactivation. There is growing interest in regulatory activities unconnected to the coding region of the genome, or exome, in addition to epigenetic control mechanisms. The altered epigenome is significant, though by no means the only, problem in the etiology of Retinoblastoma. After all, cancer development is a multistep process in which numerous dissimilar genetic, epigenetic, and posttranscriptional modifications result in a shared phenotype. This study emphasizes the most recent developments in posttranscriptional change and epigenetics related to retinoblastoma tumor biology. Here, we highlight the novel biomarkers the retinoblastoma tumor has expressed to improve patient survival.

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Section: The Cernas Axes In Rbmentioning

confidence: 99%

“…Recently, Jie Sun et al, 2023, demonstrated that the hsa_circ_0015965/lncRNA MEG3-has-miR-378a-5p-NOTCH1pathway promotes the malignant progression of RB [64]. (Table 4)…”

Section: The Cernas Axes In Rbmentioning

confidence: 99%