Identification of new thyroid hormone dependent biomarkers for a successful replacement therapy

Nock, Sebastian; Johann, Kornelia; Harder, Lisbeth; Höfig, C; Engelmann, Beatrice; Homuth, Georg; Völker, Uwe; Mittag, Jens; Brabant, Georg

doi:10.1530/endoabs.56.gp253

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“…Other systems like the apolipoproteins were reduced in parallel between mice and humans. In our interspecies comparison study between human and mice [27,36], we have already identified 16 serum proteins that are concordantly altered by T4 in both species, including a macrophagederived protein [40]. This demonstrates that such an approach has great potential to not only reveal a robust set of TH dependent biomarkers, but also to understand the underlying regulatory mechanisms and identify the involved components of the TH regulatory network or non-thyroidal regulators.…”

Section: Perspectives For New Biomarkers With Better Sensitivity To Mmentioning

confidence: 79%

Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers

Nock

Höfig

Harder

et al. 2019

Exp Clin Endocrinol Diabetes

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Thyroid function is conventionally assessed by measurement of thyroid-stimulating hormone (TSH) and free circulating thyroid hormones, which is in most cases sufficient for correct diagnosis and monitoring of treatment efficiency. However, several conditions exist, in which these parameters may be insufficient or even misleading. For instance, both, a TSH-secreting pituitary adenoma and a mutation of thyroid hormone receptor β present with high levels of TSH and circulating hormones, but the optimal treatment is substantially different. Likewise, changes in thyroid hormone receptor α signaling are not captured by routine assessment of thyroid status, as serum parameters are usually inconspicuous. Therefore, new biomarkers are urgently needed to improve the diagnostic management and monitor treatment efficiency for e. g., replacement therapy in hypothyroidism or thyroid hormone resistance. By comparing animal models to human data, the present minireview summarizes the status of this search for new tissue- and pathway-specific biomarkers of thyroid hormone action.

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Section: Perspectives For New Biomarkers With Better Sensitivity To Mmentioning

confidence: 79%

Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers

Nock

Höfig

Harder

et al. 2019

Exp Clin Endocrinol Diabetes

Self Cite

View full text Add to dashboard Cite

show abstract

Identification of new thyroid hormone dependent biomarkers for a successful replacement therapy

Cited by 1 publication

References 0 publications

Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers

Unraveling the Molecular Basis for Successful Thyroid Hormone Replacement Therapy: The Need for New Thyroid Tissue- and Pathway-Specific Biomarkers

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