Identification of New Quantitative Trait Loci (Other Than the PRNP Gene) Modulating the Scrapie Incubation Period in Sheep

Abstract

Although susceptibility to scrapie is largely controlled by the PRNP gene, we have searched for additional genomic regions that affect scrapie incubation time in sheep, using two half-sib families with a susceptible PRNP genotype and naturally infected by scrapie. Quantitative trait loci were detected on OAR6 and OAR18.

Genotypic profile of Pantanal creole sheep regarding susceptibility or resistance to scrapie

“…It is important to note that there are cases, such as those observed in Suffolk sheep and in some French breeds, in which the V 136 allele is rare. Moreover, the polymorphism that determines the degree of susceptibility is located in codon 171 (Moreno et al, 2008).…”

Detection of QTL Underlying Milk Traits in Sheep: An Update

“…Similar conclusion was drawn by De Vries et al (2005), who did not identify any significant association between the prion protein genotypes and milk performance, type or reproduction traits. QTL other than PRNP for scrapie resistance have been reported on OAR6 and OAR18 in Romanov sheep (Moreno et al, 2008;. …”

Polymorphisms in genes <i>CTSB, CTSD, CAPN2, KLK1</i> and <i>TGFB1</i> not associated with susceptibility to atypical or classical ovine scrapie

“…It has been indicated by several studies on quantitative trait loci (QTLs) in mouse and sheep that scrapie susceptibility is influenced by further gene loci besides the well known effects of prion protein (PrP) gene (PRNP) variants (LLOYD et al 2001, MORENO et al 2008, MORENO et al 2003, STEPHENSON et al 2000. This is interesting, especially in the case of atypical scrapie, where association between PrP haplotypes and susceptibility to the disease is not as stringent as in classical scrapie (LÜHKEN et al 2007, MOUM et al 2005, ORGE et al 2004.…”