Identification of new differentiation inducing factors from Dictyostelium discoideum

Saito, Tamao; Taylor, Graham W.; Yang, Ji‐Chun; Neuhaus, David; Stetsenko, Dmitry A.; Kato, Atsushi; Kay, Robert R.

doi:10.1016/j.bbagen.2005.12.006

Cited by 60 publications

(61 citation statements)

References 24 publications

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“…21) In the present study, MPBD appeared to be involved in both spore formation and the control of cell-type re-specification at the later developmental stage.…”

Section: Prespore Differentiationmentioning

confidence: 87%

“…22) In vivo assay revealed that DIF-1 induced only pstB and pstO cells and that the major prestalk cells differentiated without DIF-1. 21) Recently, cyclic di-(3,5)-guanosine monophosphate (c-di-GMP) was identified as stalk-cell inducing morphogen, 23) but the major prestalk cell inducer is not clear yet. The Dictyostelium diguanylate cyclase DgcA, which produces c-di-GMP, is expressed in the slug tip region, which consists of pstA cells.…”

Section: Prespore Differentiationmentioning

confidence: 99%

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Steely Enzymes Are Involved in Prestalk and Prespore Pattern Formation

Sato¹,

Kagami²,

Narita³

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…21) In the present study, MPBD appeared to be involved in both spore formation and the control of cell-type re-specification at the later developmental stage.…”

Section: Prespore Differentiationmentioning

confidence: 87%

Section: Prespore Differentiationmentioning

confidence: 99%

Steely Enzymes Are Involved in Prestalk and Prespore Pattern Formation

Sato¹,

Kagami²,

Narita³

et al. 2013

Bioscience, Biotechnology, and Biochemistry

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“…While MPBD was clearly identified as an extracellular factor, the time in development when it is secreted was not determined (38). Using synthetic MPBD as a standard, we established a simple purification and quantification procedure using mass spectrometry ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…All of these genes are required for the effect of external cAMP on DIF-1 stalk induction. Cells lacking GskA show increased sensitivity to DIF-1 induction of stalk cell differentiation and are refractory to the repressive effects of extracellular cAMP (38). Since we now know that GskA blocks the release of the SDF-1 precursor, the role of MBPD in overcoming cAMP inhibition of DIF-1 stalk induction can be understood as the result of inhibition of GskA activity, thereby allowing the SDF-1 precursor to be released and processed.…”

Section: Discussionmentioning

confidence: 99%

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The Polyketide MPBD Initiates the SDF-1 Signaling Cascade That Coordinates Terminal Differentiation in Dictyostelium

Anjard

Loomis

2011

Eukaryot Cell

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Dictyostelium uses a wide array of chemical signals to coordinate differentiation as it switches from a unicellular to a multicellular organism. MPBD, the product of the polyketide synthase encoded by stlA, regulates stalk and spore differentiation by rapidly stimulating the release of the phosphopeptide SDF-1. By analyzing specific mutants affected in MPBD or SDF-1 production, we delineated a signal transduction cascade through the membrane receptor CrlA coupled to G␣1, leading to the inhibition of GskA so that the precursor of SDF-1 is released. It is then processed by the extracellular protease of TagB on prestalk cells. SDF-1 apparently acts through the adenylyl cyclase ACG to activate the cyclic AMP (cAMP)-dependent protein kinase A (PKA) and trigger the production of more SDF-1. This signaling cascade shows similarities to the SDF-2 signaling pathway, which acts later to induce rapid spore encapsulation.

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Chemical Molecules that Regulate Transcription and Facilitate Cell‐to‐Cell Communication

Wüster

Babu

2008

Wiley Encyclopedia of Chemical Biology

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In this article we review cell‐to‐cell communication in three groups of organisms: bacteria, fungi, and the amoeba Dictyostelium . In particular, we concentrate on cell‐density‐dependent quorum sensing, which seems to have evolved independently on several occasions. The biologic and chemical properties of select systems are outlined, and the way they affect transcription, often via cross‐genome interactions, is described for each of the three groups. Furthermore, we give a short overview of the methods that can be used to study quorum sensing. We also outline the general properties of quorum sensing systems, such as positive feedback and its link to starvation‐dependent pathways.

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Identification of new differentiation inducing factors from Dictyostelium discoideum

Cited by 60 publications

References 24 publications

Steely Enzymes Are Involved in Prestalk and Prespore Pattern Formation

Steely Enzymes Are Involved in Prestalk and Prespore Pattern Formation

The Polyketide MPBD Initiates the SDF-1 Signaling Cascade That Coordinates Terminal Differentiation in Dictyostelium

Chemical Molecules that Regulate Transcription and Facilitate Cell‐to‐Cell Communication

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