Identification of new biologically active synthetic molecules: comparative experimental and theoretical studies on the structure-antioxidant activity relationship of cyclic 1,3-ketoamides

Kerbadou, Riad Mustapha; Aoul, Ratiba Hadjadj; Benmaati, Aouicha; Taleb, Assya; Hacini, Salih; Zahmani, Hadjira Habib

doi:10.1007/s00894-021-04705-4

Cited by 3 publications

(3 citation statements)

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“…The antioxidant activity of different nanocomposites as well as G3 dendrimer was evaluated using the DPPH radical scavenging test following the previous study of Kerbadou et al 77 The ascorbic acid was taken as a reference during this study. First, the electron transfers of the DPPH dissolved in a concentrated methanol solution produce a mauve colour.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Then, the DPPH solution is mixed with the antioxidant compound which can give a hydrogen atom and leads to the reduced form, a change of colour will be observed from the mauve colour to yellow, this is due to the radical-scavenging capacity of the molecule tested (Scheme 2). 77 All tests were performed three times. The DPPH solution and the tested samples of dendrimers with different concentrations (10-800 μg mL À1 ) were freshly prepared with an alcoholic solution.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

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Classical and ultrasonic preparation of new dendrimer–Copper nanocomposites: Application in the catalytic reduction, antioxidant, and antimicrobial activities

Zaoui

Daouadji

Beldjilali

et al. 2023

Applied Organom Chemis

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A new dendrimer based on citric acid and sebacoyl chloride was synthesized by Steglich esterification. The obtained dendrimer was used as a matrix for the dispersion of copper nanoparticles using classical and ultrasound methods. All materials were characterized by FTIR, 1H NMR, thermogravimetric analysis, X-ray photoelectron spectrometry, scanning electron microscopy, and energ-ydispersive -X-ray spectroscopy. The obtained nanocomposites were tested against two Gram-positive pathogenic bacteria (Bacillus cereus and Staphylococcus aureus), two Gram negative (Escherichia coli and Pseudomonas aeruginosa), the organic dye methylene blue, and in the 1,1-diphenyl-2-picrylhydrazile radical scavenging assay. A comparative study between both methods in structural, morphological, and thermal properties as well as in the antimicrobial, antioxidant, and catalytic reduction activities was provided. All nanocomposites showed an excellent activity for all applications. The comparison between both synthesis methods shows the superiority of the sonication methods, especially via the catalytic reduction and the antioxidant activities, the classic method allows better thermal stability and a higher metal content with some cationic oxidation state in the obtained nanocomposites, but ultrasound allows a better dispersion with a fully reduced metal.

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%