Identification of neuron-related genes for cell therapy of neurological disorders by network analysis

Su, Li-ning; Song, Xiu–Peng; H, Wei; Yin, Haifeng

doi:10.1631/jzus.b1600109

Cited by 5 publications

(3 citation statements)

References 38 publications

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“…The activation of CREB promotes the transcription of many genes associated with neuronal survival, cell differentiation and axonal growth (Freitas et al, 2013). In our previous study, we showed that CREB1 plays pivotal roles in neuronal differentiation (Su et al, 2017a). In our present study, the results showed that CREB1 plays pivotal roles in the negative regulation of axons.…”

Section: Discussionsupporting

confidence: 58%

Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration

Song

Zhou

et al. 2018

J. Zhejiang Univ. Sci. B

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Axon regeneration is crucial for recovery from neurological diseases. Numerous studies have identified several genes, microRNAs (miRNAs), and transcription factors (TFs) that influence axon regeneration. However, the regulatory networks involved have not been fully elucidated. In the present study, we analyzed a regulatory network of 51 miRNAs, 27 TFs, and 59 target genes, which is involved in axon regeneration. We identified 359 pairs of feed-forward loops (FFLs), seven important genes (Nap1l1, Arhgef12, Sema6d, Akt3, Trim2, Rab11fip2, and Rps6ka3), six important miRNAs (hsa-miR-204-5p, hsa-miR-124-3p, hsa-miR-26a-5p, hsa-miR-16-5p, hsa-miR-17-5p, and hsa-miR-15b-5p), and eight important TFs (Smada2, Fli1, Wt1, Sp6, Sp3, Smad4, Smad5, and Creb1), which appear to play an important role in axon regeneration. Functional enrichment analysis revealed that axon-associated genes are involved mainly in the regulation of cellular component organization, axonogenesis, and cell morphogenesis during neuronal differentiation. However, these findings need to be validated by further studies.

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Section: Discussionsupporting

confidence: 58%

Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration

Song

Zhou

et al. 2018

J. Zhejiang Univ. Sci. B

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“…While any diffuse hyperinflammation corrected by PLT cytokine use is welcome, numerous CNS signal pathways are impacted upon PLT activation to facilitate tissue repair, angiogenesis and neurogenesis [84]. This work therefore expands prior descriptions of PRP treatment for CNS disorders [7] given its recuperative effects in SCI and peripheral nerve damage documented elsewhere [68,85]. This approach also extends earlier PRP use in kidney disease, which balanced difficulties of treating an encapsulated solid organ with the need to dose PRP locally [86].…”

Section: Discussionmentioning

confidence: 70%

Intrathecal Autologous Thrombin-Activated Condensed Platelet Cytokines in Chronic Neurodegenerative Disease: Anti-inflammatory and Regenerative Responses, Phase I

Sills¹

2023

Preprint

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Choroid plexus insufficiency or glymphatic stasis are often classified as prequels to harmful accretion of toxic proteins in neurodegenerative disease. Cognitive decline and memory loss subsequently become cardinal features of Alzheimer’s disease (AD), typically progressing with amyloid-ß and tau protein accumulation. For Parkinson’s disease (PD), α-synuclein deposits and dopamine depletion are linked to impaired movement, resting tremor, and rigidity. Importantly, both diagnoses are accompanied by hyperinflammation and intrathecal cytokine changes. Thus far, numerous clinical trials for investigational drugs have produced nothing effective for AD or PD, yet the anti-inflammatory and regenerative potential of platelet-rich plasma (PRP) remains largely unexamined in this context. This report explores a proposed Phase I study on intrathecal condensed plasma growth factors processed from autologous thrombin-activated PRP as monotherapy for AD or PD. The concept gains support from related work where cytokines of platelet origin successfully lowered inflammation, corrected background fibrosis, deactivated abnormal cells, and recovered local tissue function—all desirable outcomes in AD and PD. PRP-mediated effects on membrane potentials, electrolyte balance, and water clearance are less well characterized, but experimental evidence suggests these pathways could likewise influence glymphatic drainage to ameliorate proteinopathies. As a well-tolerated ‘orthobiologic’ with no hypersensitivity risk, intrathecal PRP and its derivatives bring advantages distinct from synthetic pharmaceuticals. If age-associated neuroinflammation in AD and PD is an upstream event contributing to neural disruption, then dampening local oxidative stress by a patient’s own platelet cytokines (as already proven in other tissues) could offer therapeutic relevance to these neurodegenerative conditions as well.

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“…AHP's data requirement is relatively low and depends more on operator's personal thinking and experience. It decomposes every hierarchy of elements related to decision-making stepwisely and calculates the final decomposed elements' weights based on the two elements' importance 3,[12][13][14] . Lei 3 proposed an AHP-based Fuzzy Comprehensive Evaluation Model in the light of the construction of the emergency LSC of People's Armed Police Force dealing with mass emergencies.…”

Section: Fuzzy Comprehensive Evaluation Modelmentioning

confidence: 99%

Research progress on logistics support capability evaluation model and its application

Chang¹,

Zhang²,

Yin³

2022

International Conference on Computer Application and Information Security (ICCAIS 2021)

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Logistics support capability (LSC) plays an important role in troop's combat effectiveness, therefore the evaluation on LSC is the key supporting means for its improvement. This paper compared several models and their applications in the LSC evaluation area, including the Fuzzy Comprehensive Evaluation Model, Grey Evaluation Model, Network DEA (Data Envelopment Analysis) Model, evaluation models based on Belief Rule-Base (BRB) as well as evaluation models based on D-S Evidence Theory. Among these models, Fuzzy Comprehensive Evaluation Model can quantify some factors with unclear border or hard to quantify; Grey Evaluation Model is suitable for the uncertain system; Network DEA Model effectively deals with multiple inputs and outputs on the same kind of Decision-Making Units (DMUs); evaluation model based on BRB handle effectively the information uncertainty and evaluation index types diversity; evaluation model based on D-S Evidence Theory could effectively analyze the consistency of evaluation index and increase the discrimination of the evaluation. However, these evaluations mainly focus on the theoretical research and hardly can be applied in reality. In this paper, the suggestions about attention to the purpose of LSC evaluation, application of new information technology, and evaluation practicality were proposed in order to improve LCS evaluation.

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Identification of neuron-related genes for cell therapy of neurological disorders by network analysis

Cited by 5 publications

References 38 publications

Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration

Network analysis of microRNAs, transcription factors, and target genes involved in axon regeneration

Intrathecal Autologous Thrombin-Activated Condensed Platelet Cytokines in Chronic Neurodegenerative Disease: Anti-inflammatory and Regenerative Responses, Phase I

Research progress on logistics support capability evaluation model and its application

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