Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain

Stigloher, Christian; Chapouton, Prisca; Adolf, Birgit; Bally‐Cuif, Laure

doi:10.1016/j.brainresbull.2007.10.032

Cited by 43 publications

(39 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…hairy represses proneural function in the Drosophila ectoderm, acting as a prepatterning gene to promote a non-neural fate over a large territory, whereas the inhibition of proneural function by Enhancer of split [E(spl)] regulates the number of neuronal precursors in the neuroectoderm (Campos-Ortega and Jan, 1991;Campos-Ortega, 1993). During development of the central nervous system (CNS) in vertebrates, Hes factors maintain similar functions to those in Drosophila and antagonize the proneural activities of Atonal (Ath), Achaete scute (Ash) and Neurogenin (Ngn/Neurog) bHLH proteins (Ishibashi et al, 1994;Kageyama et al, 2005;Kageyama et al, 2008;Ross et al, 2003;Sasai et al, 1992;Stigloher et al, 2008). For example, in the mammalian neural tube, the activity of Hes1, Hes3 and Hes5 inhibits Mash1 (Ascl1 -Mouse Genome Informatics) and limits neuronal differentiation (Baek et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear

et al. 2011

Self Cite

View full text Add to dashboard Cite

SUMMARYProper spatial control of neurogenesis in the inner ear ensures the precise innervation of mechanotransducing cells and the propagation of auditory and equilibrium stimuli to the brain. Members of the Hairy and enhancer of split (Hes) gene family regulate neurogenesis by inhibiting neuronal differentiation and maintaining neural stem cell pools in non-neurogenic zones. Remarkably, their role in the spatial control of neurogenesis in the ear is unknown. In this study, we identify her9, a zebrafish ortholog of Hes1, as a key gene in regulating otic neurogenesis through the definition of the posterolateral non-neurogenic field. First, her9 emerges as a novel otic patterning gene that represses proneural function and regulates the extent of the neurogenic domain. Second, we place Her9 downstream of Tbx1, linking these two families of transcription factors for the first time in the inner ear and suggesting that the reported role of Tbx1 in repressing neurogenesis is in part mediated by the bHLH transcriptional repressor Her9. Third, we have identified retinoic acid (RA) signaling as the upstream patterning signal of otic posterolateral genes such as tbx1 and her9. Finally, we show that at the level of the cranial otic field, opposing RA and Hedgehog signaling position the boundary between the neurogenic and non-neurogenic compartments. These findings permit modeling of the complex genetic cascade that underlies neural patterning of the otic vesicle.

show abstract

Section: Introductionmentioning

confidence: 99%

Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear

et al. 2011

Self Cite

View full text Add to dashboard Cite

show abstract

“…La MHB est également un réservoir de cellules progénitrices, dont le recrutement progressif assure la neurogenèse més-et rhombencéphalique. Le maintien des cellules progénitrices de la MHB dépend de facteurs de transcription de type Hairy/E(Spl) (hairy/enhancer of split) : Hes (Hes1/3/5) chez la souris, Her (Her5/9) chez Danio [4] (Figure 1B). Afin d'assurer la cohérence des fonctions de la MHB, il est important que l'expression des facteurs Fgf et Hes/Her soit maintenue en phase après leur induction initiale.…”

Section: Régionalisation Et Frontières Au Cours Du Développement Céréunclassified

Microrégulation aux frontières (cérébrales)

Coolen

Bally‐Cuif

2008

Med Sci (Paris)

Self Cite

View full text Add to dashboard Cite

“…Numerous studies have shown that cells within the MHB remain as slowly proliferating, non-differentiating progenitor cell populations [25][26][27]. Studies in zebrafish and mice have highlighted the role of the Notch effector group of Hes genes, which are expressed in MHB cells, to repress them from undergoing differentiation while promoting neurogenesis in the adjacent domains [28][29][30][31][32][33].…”

Section: Introductionmentioning

confidence: 99%

A New Role of Hindbrain Boundaries as Pools of Neural Stem/Progenitor Cells Regulated by Sox2

Sela-Donenfeld

Peretz

2017

Mechanisms of Development

View full text Add to dashboard Cite

Background: Compartment boundaries are an essential developmental mechanism throughout evolution, designated to act as organizing centers and to regulate and localize differently fated cells. The hindbrain serves as a fascinating example for this phenomenon as its early development is devoted to the formation of repetitive rhombomeres and their well-defined boundaries in all vertebrates. Yet, the actual role of hindbrain boundaries remains unresolved, especially in amniotes.Results: Here, we report that hindbrain boundaries in the chick embryo consist of a subset of cells expressing the key neural stem cell (NSC) gene Sox2. These cells co-express other neural progenitor markers such as Transitin (the avian Nestin), GFAP, Pax6 and chondroitin sulfate proteoglycan. The majority of the Sox2 + cells that reside within the boundary core are slow-dividing, whereas nearer to and within rhombomeres Sox2 + cells are largely proliferating. In vivo analyses and cell tracing experiments revealed the contribution of boundary Sox2 + cells to neurons in a ventricular-to-mantle manner within the boundaries, as well as their lateral contribution to proliferating Sox2 + cells in rhombomeres. The generation of boundary-derived neurospheres from hindbrain cultures confirmed the typical NSC behavior of boundary cells as a multipotent and self-renewing Sox2 + cell population. Inhibition of Sox2 in boundaries led to enhanced and aberrant neural differentiation together with inhibition in cell-proliferation, whereas Sox2 mis-expression attenuated neurogenesis, confirming its significant function in hindbrain neuronal organization.

show abstract

Identification of neural progenitor pools by E(Spl) factors in the embryonic and adult brain

Cited by 43 publications

References 63 publications

Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear

Her9 represses neurogenic fate downstream of Tbx1 and retinoic acid signaling in the inner ear

Microrégulation aux frontières (cérébrales)

A New Role of Hindbrain Boundaries as Pools of Neural Stem/Progenitor Cells Regulated by Sox2

Contact Info

Product

Resources

About