Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

McKerracher, Lisa; David, Samuel; Jackson, David; Kottis, Vicky; Dunn, Robert; Braun, Peter E.

doi:10.1016/0896-6273(94)90247-x

Cited by 1,042 publications

(703 citation statements)

References 51 publications

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“…This is partly attributable to direct inhibitory effects exerted by MAG (McKerracher et al, 1994), which has been shown to inhibit neuronal process outgrowth in numerous studies, as reviewed elsewhere (McKerracher and Winton, 2002). It has also been reported that soluble dMAG species secreted from damaged white matter are able to inhibit axonal regeneration (Tang et al, 2001;Tang et al, 1997b).…”

Section: Mmp-7 Generated Mag Fragments Inhibit Neuronal Process Outgrmentioning

confidence: 96%

Cleavage of myelin associated glycoprotein by matrix metalloproteinases

Milward

Kim

Szklarczyk

et al. 2008

Journal of Neuroimmunology

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Derivative myelin associated glycoprotein (dMAG) results from proteolysis of transmembrane MAG and can inhibit axonal growth. We have tested the ability of certain matrix metalloproteinases Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Section: Mmp-7 Generated Mag Fragments Inhibit Neuronal Process Outgrmentioning

confidence: 96%

Cleavage of myelin associated glycoprotein by matrix metalloproteinases

Milward

Kim

Szklarczyk

et al. 2008

Journal of Neuroimmunology

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“…Myelin-associated glycoprotein was the first myelin inhibitor to be identified (Mukhopadhyay et al, 1994;McKerracher et al, 1994). Myelin-associated glycoprotein is a member of the immunoglobulin (Ig)-like family (Salzer et al, 1987(Salzer et al, , 1990.…”

Section: Myelin-associated Glycoproteinmentioning

confidence: 99%

Myelin—Associated Inhibitory Signaling and Strategies to Overcome Inhibition

Chaudhry

Filbin

2006

J Cereb Blood Flow Metab

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Numerous studies in the last two decades have resulted in significant progress in our understanding of the role of inhibitors on axonal regeneration and conditions that influence mature neurons to regrow in an inhibitory environment. These studies have revealed putative therapeutic targets and strategies to interfere in the inhibitory signaling cascade and promote axonal regeneration. Some agents that were successful in animal models are now being tested in human patients. All of these advances have raised hope of a cure for an injury that was once thought to be 'an ailment for which nothing is done' (Quote from Edwin Smith surgical papyrus, 1600BC).

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“…In fact, Nogo -now known to exist in three isoforms 35,36 -is but one of a number of myelin-derived inhibitory proteins. Others identified thus far include myelinassociated glycoprotein (MAG) 37,38 and oligodendrocyte myelin glycoprotein (OMgp). 39 The role of MAG as an impediment to axonal regeneration is exemplified by in vitro studies in which its immunodepletion from myelin extracts attenuated inhibitory activity.…”

Section: Myelin and Myelin Signaling: An Inhibitory Chorus Linementioning

confidence: 99%

“…39 The role of MAG as an impediment to axonal regeneration is exemplified by in vitro studies in which its immunodepletion from myelin extracts attenuated inhibitory activity. 37 It has since been shown that elevating cAMP can stimulate adult neurons to extend axons on MAG substrates, 40 an effect related to the growth-enhancing effects of conditioning lesions and neurotrophic factor application (see below). Studies in MAG knockout mice have been equivocal, however, since myelin preparations from these mice are still effective in blocking regeneration, and since severed optic nerve and corticospinal tract (CST) axons regenerate no better in MAG knockouts than in wildtype mice.…”

Section: Myelin and Myelin Signaling: An Inhibitory Chorus Linementioning

confidence: 99%

Setting the stage for functional repair of spinal cord injuries: a cast of thousands

2005

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Here we review mechanisms and molecules that necessitate protection and oppose axonal growth in the injured spinal cord, representing not only a cast of villains but also a company of therapeutic targets, many of which have yet to be fully exploited. We next discuss recent progress in the fields of bridging, overcoming conduction block and rehabilitation after spinal cord injury (SCI), where several treatments in each category have entered the spotlight, and some are being tested clinically. Finally, studies that combine treatments targeting different aspects of SCI are reviewed. Although experiments applying some treatments in combination have been completed, auditions for each part in the much-sought combination therapy are ongoing, and performers must demonstrate robust anatomical regeneration and/or significant return of function in animal models before being considered for a lead role.Spinal Cord (2005) 43, 134-161.

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Identification of myelin-associated glycoprotein as a major myelin-derived inhibitor of neurite growth

Cited by 1,042 publications

References 51 publications

Cleavage of myelin associated glycoprotein by matrix metalloproteinases

Cleavage of myelin associated glycoprotein by matrix metalloproteinases

Myelin—Associated Inhibitory Signaling and Strategies to Overcome Inhibition

Setting the stage for functional repair of spinal cord injuries: a cast of thousands

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