Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients

Fonseca, Simone Gonçalves; Moins‐Teisserenc, Hélène; Clave, Emmanuel; Ianni, Bárbara Maria; Nunes, Vera Lopes; Mady, Charles; Iwai, Leo Kei; Sette, Alessandro; Sidney, John; Marin, Maria Lúcia Carnevale; Goldberg, Anna Carla; Guilherme, Luiza; Charron, Dominique; Toubert, Antoine; Kalil, Jorge; Cunha-Neto, Edécio

doi:10.1016/j.micinf.2005.01.001

Cited by 67 publications

(55 citation statements)

References 35 publications

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“…As discussed above, T cruzi antigen and DNA have been identified in cardiac tissue from chronic Chagas disease patients, and T cruzi-specific CD8ϩ T cells were isolated in endomyocardial biopsy material from patients with Chagas heart disease. 121 This provides evidence for the recruitment and expansion of T cruzi-specific T cells to the myocardium, possibly related to parasite persistence in the chronic phase of Chagas heart disease. The T cruzi materials found in the myocardium of chronic chagasic patients are definitely scarce, however, in comparison with…”

Section: Parasite Antigen-driven Immunopathology and Autoimmunity In mentioning

confidence: 79%

Pathogenesis of Chronic Chagas Heart Disease

Marin-Neto

Cunha-Neto²,

Maciel³

et al. 2007

Circulation

693

619

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Background-Chagas disease remains a significant public health issue and a major cause of morbidity and mortality in Latin America. Despite nearly 1 century of research, the pathogenesis of chronic Chagas cardiomyopathy is incompletely understood, the most intriguing challenge of which is the complex host-parasite interaction. Methods and Results-A systematic review of the literature found in MEDLINE, EMBASE, BIREME, LILACS, and SCIELO was performed to search for relevant references on pathogenesis and pathophysiology of Chagas disease. Evidence from studies in animal models and in anima nobile points to 4 main pathogenetic mechanisms to explain the development of chronic Chagas heart disease: autonomic nervous system derangements, microvascular disturbances, parasite-dependent myocardial aggression, and immune-mediated myocardial injury. Despite its prominent peculiarities, the role of autonomic derangements and microcirculatory disturbances is probably ancillary among causes of chronic myocardial damage. The pathogenesis of chronic Chagas heart disease is dependent on a low-grade but incessant systemic infection with documented immune-adverse reaction. Parasite persistence and immunological mechanisms are inextricably related in the myocardial aggression in the chronic phase of Chagas heart disease. Conclusions-Most clinical studies have been performed in very small number of patients. Future research should explore the clinical potential implications and therapeutic opportunities of these 2 fundamental underlying pathogenetic mechanisms.

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Section: Parasite Antigen-driven Immunopathology and Autoimmunity In mentioning

confidence: 79%

Pathogenesis of Chronic Chagas Heart Disease

Marin-Neto

Cunha-Neto²,

Maciel³

et al. 2007

Circulation

693

619

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“…Although it is difficult to definitively prove that these cells are important to host resistance, it is plausible that they exert an anti-parasitic effect similar to that seen in the mouse model of infection. During the chronic phase of the disease, most inDuring the chronic phase of the disease, most individuals have strong CMI to parasite antigens (Morato et al 1986, Cetron et al 1993, Dutra et al 1996, BarrosMazon et al 1997, Wizel et al 1998b, Ribeirão et al 2000, Fonseca et al 2005, Albareda et al 2006, Alvarez et al 2008. Events causing depression of CMI, such as immuno-suppressive treatment or HIV infection, lead to the relatively fast development of symptomatic forms of the disease in a percentage of chagasic patients (Rocha et al 1994).…”

Section: Cd4 + and Cd8 + T Cells Are Important Factors In Mediating Hmentioning

confidence: 99%

Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

Rodrigues¹,

Alencar²,

Claser³

et al. 2009

Mem. Inst. Oswaldo Cruz

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“…On the other hand, the presence of parasite antigen and DNA in host tissues during the chronic phase of Chagas disease (reviewed in HIGUCHI et al, 2003), although very scarce, may be relevant for maintaining T. cruzi-specific immune responses. Furthermore, T. cruzi-specific CD8+ T cells have been isolated from endomyocardial biopsies of a CCC patient (FONSECA et al, 2005), providing evidence for the recruitment and expansion of T. cruzi-specific T cells in the myocardium, possibly related to the presence of the parasite antigen. In experimental T. cruzi infection, a higher inoculum (BILATE et al, 2003) or higher parasite load in the acute phase (MARINHO et al, 1999) are associated with more aggressive heart disease, suggesting a relationship between parasite burden and severity of disease in animal models.…”

Section: Immunopathogenesis Of Chagas Disease Cardiomyopathymentioning

confidence: 98%

Chagas disease cardiomyopathy: current concepts of an old disease

Bilate¹,

Cunha‐Neto

2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYChagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy known as Chagas disease cardiomyopathy (CCC). Data from both murine models and human studies support the view that an autoimmune response as well as a parasite-driven immune response involving inflammatory cytokines and chemokines may both play a role in generating the heart lesions leading to CCC. This review aims to summarize recent advances in the understanding of the immunopathogenesis of Chagas disease cardiomyopathy.

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Identification of multiple HLA-A*0201-restricted cruzipain and FL-160 CD8+ epitopes recognized by T cells from chronically Trypanosoma cruzi-infected patients

Cited by 67 publications

References 35 publications

Pathogenesis of Chronic Chagas Heart Disease

Pathogenesis of Chronic Chagas Heart Disease

Swimming against the current: genetic vaccination against Trypanosoma cruzi infection in mice

Chagas disease cardiomyopathy: current concepts of an old disease

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